An intra- and intercellular journey in the skin.
Skin color relies mainly on two cell types, the melanocytes and the keratinocytes. In the epidermis, the melanocytes generate a membrane-bound organelle called the melanosome in which melanin pigments are synthesized, stored and transferred to the neighboring keratinocytes, the pigment-receiving cells. The entire process is fully coordinated in space and time and requires the integration of extracellular signals and their translation into intracellular events. They include the modulation of signaling cascades, genes transcription, membrane trafficking or cell-cell contacts that lead ultimately to body photoprotection.
Our current work aims at deciphering the molecular mechanisms underlying such coordination at the cell and tissue levels and whether these pathways are the targets of pigmentary disorders. I will present some of our recent data highlighting how the local remodeling of the melanosome membrane impacts on its homeostasis and function, and how the signaling and mechanics of melanocytes contribute to tissue pigmentation. That will illustrate some of the intracellular and intercellular events underlying one prominent feature of humans.
Invité par Marie-Dominique GALIBERT
>> vendredi 27 septembre 2019 à 11h00' - salle de conférence de l'IGDR, rez-de-chaussée, bâtiment 4/ Villejean Campus
Séminaire en anglais, entrée libre dans la limite des places disponibles