Advanced microscopy sheds light on tumor resistance to anti-cancer drugs

Scientists from the Institute of Genetics and Development in Rennes, in collaboration with Hungarian colleagues, have mobilized a microscopy platform from the University of Rennes 1 to shed light on the mechanisms of resistance of tumor cells to certain treatments. Publications in Science Advances and Nature Communication (Dec. 2020).

Identifying the proteins involved in DNA repair mechanisms is the backdrop to the work being carried out at the IGDR by Sébastien Huet, lecturer at the University of Rennes 1 and Rebecca Smith, post-doctoral fellow from New Zealand.

Indeed, our DNA, the "building block" of our body, suffers more than 100,000 damages per day. Cellular mechanisms constantly repair it to maintain the integrity of our genome and keep our cells functional.

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