Adult stem cell control: From lineage decisions to genome stability
Allison BARDIN - Stem cells and tissue homeostasis, Institut Curie (Paris, France)
Adult stem cells are long-lived residents in adult tissues acting to replenish terminally differentiated cells. My seminar will explore two important questions of adult stem cell biology using the Drosophila intestinal stem cell model system: how are terminal cell fate decisions controlled and how stable is the genome of adult stem cells? I will present evidence that secretory cell fate specification requires Numb to inhibit Notch activity and I will discuss mechanisms upstream and downstream allowing EE cell fate specification. In a second part, I will present our finding of frequent spontaneous mutations in adult intestinal stem cells and their effects on the adult tissue.
Invited by Roland LE BORGNE
>> Friday, March 18 , at 11:00 - IGDR conference room (ground floor of Building 4 / Villejean Campus)
Seminar in English