Robustness is an ambivalent property because it allows proper development, from a one-cell embryo to a complex multicellular organism such as human, but also contribute to genesis and resisting of cancerous cells, because it allows tumor cells to resist anti-cancer drugs and to develop despite the many errors that they have accumulated.
Microtubule Feedback and LET-99-Dependent Control of Pulling Forces Ensure Robust Spindle Position.
Bouvrais H, Chesneau L, Pastezeur S, Fairbrass D, Delattre M, Pécréaux J.
Biophys J. 2018 Dec
The polarity-induced force imbalance in Caenorhabditis elegans embryos is caused by asymmetric binding rates of dynein to the cortex.
Rodriguez-Garcia R, Chesneau L, Pastezeur S, Roul J, Tramier M, Pécréaux J.
Mol Biol Cell. 2018 Dec
The Mitotic Spindle in the One-Cell C. elegans Embryo Is Positioned with High Precision and Stability.
Pécréaux J, Redemann S, Alayan Z, Mercat B, Pastezeur S, Garzon-Coral C, Hyman AA, Howard J.
Biophys J. 2016 Oct.
Evolutionary comparisons reveal a positional switch for spindle pole oscillations in Caenorhabditis embryos.
Riche S, Zouak M, Argoul F, Arneodo A, Pecreaux J and Delattre M.
J Cell Biol. 2013 May
Membrane invaginations reveal cortical sites that pull on mitotic spindles in one-cell C. elegans embryos.
Redemann S, Pecreaux J, Goehring NW, Khairy K, Stelzer EH, Hyman AA and Howard J.
PLoS One. 2010 Aug.
Spindle oscillations during asymmetric cell division require a threshold number of active cortical force generators.
Pecreaux J, Roper JC, Kruse K, Julicher F, Hyman AA, Grill SW and Howard J.
Curr Biology. 2006 Nov.