Claude Prigent group

Cell division ensures immortality. To prepare its division the cell must replicate its chromosomes and divide them into two identical batches during mitosis. The team studies the regulation of these processes and their involvement in human pathologies.

Selected publications

  • Aurora kinase A localises to mitochondria to control organelle dynamics and energy production
    Bertolin G*, Bulteau AL, Alves-Guerra MC, Burel A, Lavault MT, Gavard O, Le Bras S, Gagné JP, Poirier GG, Le Borgne R, Prigent C*, Tramier M*
    Elife. 2018 [Epub ahead of print]

    Aurora A activation in mitosis promoted by BuGZ.
    Huang Y, Li T, Ems-McClung SC, Walczak CE, Prigent C, Zhu X, Zhang X, Zheng Y.
    J Cell Biol. 2018 Jan

    A FRET biosensor reveals spatiotemporal activation and functions of aurora kinase A in living cells.
    Bertolin G, Sizaire F, Herbomel G, Reboutier D, Prigent C, Tramier M.
    Nat Commun. 2016 Sep

    Annexin A2 is  required for the early steps of cytokinesis.
    Benaud C, Le Dez G, Mironov S, Galli F, Reboutier D, Prigent C.
    EMBO Rep. 2015 Apr.

    Sororin pre-mRNA splicing is  required for proper sister chromatid cohesion in human cells.
    Watrin E, Demidova M, Watrin T, Hu Z, Prigent C.
    EMBO Rep. 2014 Sep.
    >> Journal cover

    Aurora A is involved in central spindle assembly through phosphorylation of Ser 19 in P150Glued.
    Reboutier D*, Troadec MB*, Cremet JY, Chauvin L, Guen V, Salaun P, Prigent C.
    J Cell Biol. 2013 Apr. - * Equal contribution

    HDAC8 mutations in Cornelia de Lange syndrome affect the cohesin acetylation cycle.
    Deardorff MA, Bando M, Nakato R, Watrin E, Itoh T, Minamino M, Saitoh K, Komata M, Katou Y, Clark D, Cole KE, De Baere E, Decroos C, Di Donato N, Ernst S, Francey LJ, Gyftodimou Y, Hirashima K, Hullings M, Ishikawa Y, Jaulin C, Kaur M,  Kiyono T, Lombardi PM, Magnaghi-Jaulin L, Mortier GR, Nozaki N, Petersen MB, Seimiya H, Siu VM, Suzuki Y, Takagaki K, Wilde JJ, Willems PJ, Prigent C, Gillessen-Kaesbach G, Christianson DW, Kaiser FJ, Jackson LG, Hirota T, Krantz ID, Shirahige K.
    Nature. 2012 Sep.

    Nucleophosmin/B23 activates Aurora A at the centrosome through phosphorylation of serine 89.
    Reboutier D*, Troadec MB*, Cremet JY, Fukasawa K, Prigent C.
    J Cell Biol. 2012 Apr. - * Equal contribution