Edouard CADIEU

Equipe Génétique du Chien

Email : edouard [dot] cadieu [at] univ-rennes1 [dot] fr

Phone : +33 (0)2 23 23 44 84

Office number : Villejean /Bât 4 / Pièce 219-2

In a few words

I'm research engineer (IR-CDI) at the University of Rennes 1.

  • I first participated, as an engineer in the « Canine Genetics » team lead by Pr. Francis Galibert, to the mapping of 10 000 genes on the dog genome using the radiation hybrid technique. I have contributed to the development and the validation of the radiation hybrid panel and then to the mapping of the 10 000 genes.
  • Then I joined Dr Elaine Ostrander’s team at the NHGRI (NIH, Bethesda, USA) for my PhD. I was particularly interested in the identification of loci implicated in different phenotypes. Indeed I performed genome wide association studies to find loci implicated in histiocytic sarcoma in the Bernese mountain dog breed. By using genotyping data of 800 individuals of 80 breeds, I also identified three genes and their mutation that, by different combinations, are responsible of the diversity of the dog fur.
  • Since 2009, I joined Dr Catherine André’s team to study dog melanoma. Indeed the dog model is interesting in comparative oncology to better understand the molecular mechanism implicated in the human melanoma.
    • One of the objectives is to characterize the different dog melanoma sub-types concerning their epidemiology, clinic and histopathology.
    • Another objective is to identify the predisposing genes by genotyping cohort affected and unaffected dogs and analyzing these data by breed and melanoma subtypes.
    • Lastly, this project also aims to identify somatic alterations and metabolic pathways implicated in the tumor progression by transcriptomic analysis and tumors DNA sequencing.

Shared responsibilities

  • Assistant of the manager of the Sanger sequencing plateform.
  • Installation of new softwares and computer for people arriving in the team, data backup.

Majors publications