Anne-Laure BULTEAU

"The bacteria that whisper at the gut mitochondria"

Human mitochondria are descendants of microbes and altered mitochondrial function has been implicated in processes ranging from ageing to diabetes. 

Mitochondria are organelles within each cell that are crucial for ATP production and are also a major producer of reactive oxygen species (ROS). Recent evidence shows there is a bidirectional interaction between mitochondria and microbiota. The gut microbiota has been shown to regulate key transcriptional co-activators, transcription factors and enzymes involved in mitochondrial biogenesis such as PGC-1α, SIRT1, and AMPK genes. Furthermore, the gut microbiota and its metabolites, such as short chain fatty acids and secondary bile acids, also contribute to host energy production, ROS modulation and inflammation in the gut. On the other hand, mitochondria, particularly mitochondrial ROS production, have a crucial role in regulating the gut microbiota via modulating intestinal barrier function and mucosal immune responses. Diet is also known to dramatically modulate the composition of the gut microbiota. Therefore, studies targeting the gut microbiota can be useful for managing mitochondrial related ROS production, pro-inflammatory signals and metabolic limits. Using gnotobiotic flies and mice, we have demonstrated the ability of a specific strain Lactobacillus Plantarum to promote juvenile growth upon chronic undernutrition. These discoveries suggest that the still unknown molecular mechanisms underlying microbiota-mediated juvenile growth promotion are likely conserved during evolution. We now aim to probe the mechanistic basis of such phenomena by looking at the crosstalk between mitochondria and this specific bacteria in flies , mice and human.

Anne-Laure BULTEAU, Institut de génomique fonctionnelle de Lyon - l'ENS de Lyon - France

Invited by Giulia BERTOLIN

>> Friday 14 June 2019 at 11:00 - IGDR conference room, ground floor, building 4 / Villejean Campus

 

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