Mining of large scale molecular data in cancer. From basic research to clinical applications

The goal of the Molecular Oncology team is to identify genetic and epigenetic events involved in tumor progression and new therapeutic targets. We focus on a common cancer, bladder carcinoma, and on retinoblastoma, a rare pediatric cancer of the retina. We use bioinformatics, based on large-scale transcriptomic, genomic and sequencing data, to identify genes and pathways potentially involved in tumor progression. We then validate candidates experimentally in both cell lines and animal models (xenografts, transgenic mice and/or chemically induced mouse models). Although our work is primarily focused on the understanding of human cancers, the results obtained can be the basis of new treatments, new diagnostic and prognostic markers. Our work involves close collaboration between biologists, clinicians, pathologists, bioinformaticians and statisticians.

François Radvanyi, Équipe Oncologie Moléculaire, Institut Curie, Paris

Invited by Marie-Dominique GALIBERT

>> Friday 10 May 2019 at 11:00 - IGDR conference room, ground floor, building 4 / Villejean Campus


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