Regulation and dynamics of DNA repair in a chromatin context

Our cells receive tens of thousands of different DNA lesions per day. Failure to repair these lesions will lead to cell death, mutations and genome instability, which contribute to human diseases such as neurodegenerative disorders and cancer. Efficient recognition and repair of DNA damage, however, is complicated by the fact that genomic DNA is packaged, through histone and non-histone proteins, into a condensed structure called chromatin. The DNA repair machinery has to circumvent this barrier to gain access to the damaged DNA and repair the lesions. By using a cross-disciplinary approach that combines cutting-edge genomics approaches with bioinformatics, genetics, biochemistry and high-resolution microscopy, we identified several chromatin-modifying enzymes as key regulators of DNA repair in chromatin. In my lecture I will provide an overview of our knowledge of how these enzymes orchestrate DNA repair in chromatin and present our ongoing research in this area.

Haico Van Attikum, Leiden University Medical Center, The Netherlands

invited by Sébastien HUET

>> Monday, September 16, 2019 at 11:00 - Amphitheatre D (building 2) Campus Villejean

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