Magali SUZANNE

Cell delamination is actively involved in tissue morphogenesis

Magali SUZANNE - CBI (Toulouse, france)

Invitée par Roland LE BORGNE

abstract

Mechanical forces are critical regulators of cell shape changes and tissue remodelling during developmental morphogenetic processes. Within epithelial sheets, planar forces are specifically generated at the apical or basal cell level, while orthogonal forces are developed along the apico-basal cell axis. Although planar forces have been extensively studied, the importance and the cellular machinery required to generate orthogonal forces along the cell apico-basal axis remain elusive. Recently, we revealed that apoptotic cells are generating apico-basal forces that constitutes an important mechanical signal involved in epithelial folding in the developing leg of Drosophila. We further identified the cellular mechanism involved and showed that during the initial force-producing stage, cells reorganize their actomyosin cytoskeleton to create a contractile tether connecting to multiple anchoring points within the cell. We then ask if this mechanism was specific to apoptotic cells or could be a general feature of delaminating cells. Interestingly, we revealed that cells undergoing EMT also generate an apico-basal force and that this force constitutes a crucial driving force in mesoderm invagination. Thus, the capability to drive tissue remodelling by generating apico-basal forces could be a general feature of delaminating cells.

>> Friday, december 15, 2017 at 11:00 - IGDR conference room (ground floor of Building 4 / Villejean Campus)

Seminar in English, free entry subject to availability

Subscribe to our newsletter