Cytonuclear shuttling of β-arrestin2 regulates the Mdm2-p53 signal loop

Research Summary

Our group investigates signalling mechanisms controlling Tumour Suppressors (e.g. PTEN and p53) and Oncoproteins (e.g. Mdm2) that play decisive roles in cell fate. We have a particular focus on understanding how post-translational modifications and protein-protein interactions influence spatiotemporal control of these key proteins and how such regulation may go awry in cancer biology settings.

We previously demonstrated that the molecular scaffold protein β-arrestin2 actively shuttles through the nucleus altering Mdm2 subcellular distribution with consequences for p53 signalling. I will present recent unpublished data on how Small Ubiquitin-like MOdifier (SUMO) influences nucleocytoplasmic shuttling of β-arrestin2 to control the Mdm2-p53 pathway.  

Mark SCOTT, de l'Institut Cochin, Paris

Invited by Marc TRAMIER

>> Friday 18 October 2019 at 11:00 - IGDR conference room, ground floor, building 4 / Villejean Campus


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