Guillaume Halet Group

Using microscopic techniques, molecular biology, and genetics, our team is studying the molecular mechanisms that promote the good development of the oocyte, fertilization, the early stages of embryo development and its implantation into the uterus. We use the mouse as a model organism.


Ran promotes oocyte polarization by regulating ERM (Ezrin/Radixin/Moesin) inactivation.
Dehapiot B, Halet G.
Cell Cycle. 2013 Jun.

Polarized Cdc42 activation promotes polar body protrusion and asymmetric division in mouse oocytes.
Dehapiot B, Carrière V, Carroll J, Halet G.
Dev Biol. 2013 May.

Involvement of ITIH5, a Candidate Gene for Congenital Uterovaginal Aplasia (Mayer-Rokitansky-Küster-Hauser Syndrome), in Female Genital Tract Development.
Morcel, K, Watrin T, Jaffre F, Deschamps S, Omilli F, Pellerin I, Levêque J, Guerrier D.
Gene Expr. 2012.

Constitutive PtdIns(3,4,5)P3 synthesis promotes the development and survival of early mammalian embryos.
Halet G, Viard P, Carroll J.
Development. 2008 Feb.

Rac activity is polarized and regulates meiotic spindle stability and anchoring in mammalian oocytes.
Halet G, Carroll J.
Dev Cell. 2007 Feb.