Email : Jean-Pierre [dot] Tassan [at] univ-rennes1 [dot] fr
Phone : 02 23 23 46 89
My main interest is to understand how epithelial integrity, ensured by cell-cell junctions, is preserved during cell division. The Xenopus embryo epithelium offers a unique opportunity to study the role cell-cell junctions in situ in a developing vertebrate embryo. I use expression of fluorescently tagged proteins, knockdown and live imaging to study the roles of cell-cell junctions during cytokinesis.
1- Tight junction-associated protein GEF-H1 in the neighbours of dividing epithelial cells is essential for adaptation of cell-cell membrane during cytokinesis. Hatte G, Prigent C, Tassan JP. Exp Cell Res. 2018 Oct 1;371(1):72-82. doi: 10.1016/j.yexcr.2018.07.042.
2- Tight junctions negatively regulate mechanical forces applied to adherens junctions in vertebrate epithelial tissue. Hatte G, Prigent C, Tassan JP. J Cell Sci. 2018 Feb 5;131(3):jcs208736. doi: 10.1242/jcs.208736.
3-Epithelial cell division in the Xenopus laevis embryo during gastrulation. Hatte G, Tramier M, Prigent C, Tassan JP. Int J Dev Biol. 2014;58(10-12):775-81. doi: 10.1387/ijdb.140277jt.
4- A functional analysis of MELK in cell division reveals a transition in the mode of cytokinesis during Xenopus development. Le Page Y, Chartrain I, Badouel C, Tassan JP. J Cell Sci. 2011 Mar 15;124(Pt 6):958-68. doi: 10.1242/jcs.069567.