PhD Thesis - Biomechanics and Morphogenesis

  • Date Released: 02/16/2017
  • Position taken: October 2017
  • Assignment: Institute of Genetics and Development of Rennes - Michaux group
  • Location: Villejean Health Campus, Rennes
  • Key words: Biomechanics / Signalling / Morphogenesis / Development / C. elegans
  • Techniques: Imaging / Genetics / Gene editing / Biochemistry
  • Founding: 3-year PhD fellowship
  • Closing date for applications : Mai 31st, 2017

Characterisation of a biomechanical signalling pathway required for coordinated morphogenesis

Animal development requires the coordination of growth, which controls cell proliferation, and morphogenesis which controls the acquisition of a particular shape. Coordinated morphogenesis between different organs and tissues is usually controlled by classical biochemical signalling pathways (Notch, Hedgehog, Wnt etc). However morphogenesis can also be controlled by a biomechanical rather than a biochemical signal. It is particularly the case for the elongation step of C. elegans embryonic morphogenesis. This signalling pathway covers three tissues: a mechanical signal generated by muscle contractions is received by the dorsoventral epidermis (Zhang et al, Nature, 471-99) which transmits it to the lateral epidermis where it controls the establishment of a planar polarity required for elongation (Gillard et al, in prep).

The purpose of the PhD project is to decipher this biomechanical transtissular signalling pathway by identifying and characterising the molecular mechanisms allowing the signal transduction between the three tissues and the control of embryonic morphogenesis.

To apply

For application, Please send to Grégoire MICHAUX (format .pdf, .doc ou .docx) :

  • Curriculum Vitae (CV)
  • Cover letter
  • 2 ou 3 referencies

 

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