"Microtubules, from Tubulin to Spindles" Team

The MiToS team, led by Romain Gibeaux, investigates the relationships between structure and function of an essential eukaryotic cell component, the microtubule. These 25 nm fibers are involved in fundamental processes such as cell motility, intracellular trafficking, cell compartmentalization, or chromosome segregation during cell division.

Selected publications

Structural heterogeneity of the microtubules lattice
Guyomar C, Ku S, Heumann J, Bousquet C, Guilloux G, Gaillard N, Heichette C, Duchesne L, Steinmetz M. O, Gibeaux R, Chrétien D
bioRxiv 2021.07.14.452321

Structural model for differential cap maturation at growing microtubule ends 
Estévez-Gallego J*, Josa-Prado F*, Ku S*, Buey RM, Balaguer FA, Prota AE, Lucena-Agell D, Kamma-Lorger C, Yagi T, Iwamoto H, Duchesne L, Barasoain I, Steinmetz MO, Chrétien D, Kamimura S, Díaz JF, Oliva MA
Elife 2020 Mar.
*Co-first authors

Paternal chromosome loss and metabolic crisis contribute to hybrid inviability in Xenopus.
Gibeaux R, Acker R, Kitaoka M, Georgiou G, van Kruijsbergen I, Ford B, Marcotte EM, Nomura DK, Kwon T, Veenstra GJC, Heald R
Nature. 2018 Jan.

EB1 interacts with outwardly curved and straight regions of the microtubule lattice
Guesdon A*, Bazile F*, Buey RM, Mohan R, Monier S, Rodríguez García R, Angevin M, Heichette C, Wieneke R, Tampé R, Duchesne L, Akhmanova A, Steinmetz MO, Chrétien D
Nat Cell Biol. 2016 Sep.
*Co-first authors

The formation of ordered nanoclusters controls cadherin anchoring to actin and cell–cell contact fluidity
Strale PO, Duchesne L, Peyret G, Montel L, Nguyen T, Png E, Tampé R, Troyanovsky S, Hénon S, Ladoux B, Mège RM
J Cell Biol. 2015 Jul.

Transport of Fibroblast Growth Factor 2 in the Pericellular Matrix Is Controlled by the Spatial Distribution of Its Binding Sites in Heparan Sulfate
Duchesne L, Octeau V, Bearon RN, Beckett A, Prior I, Lounis B, Fernig DG
PLoS Biol. 2012 Jul.

Procentriole assembly revealed by cryo-electron tomography
Guichard P, Chrétien D, Marco S, Tassin AM
Embo J. 2010 May.

EB1 regulates microtubule dynamics and tubulin sheet closure in vitro
Vitre B, Coquelle FM, Heichette C, Garnier C, Chrétien D, Arnal I
Nat Cell Biol. 2008 Apr.