Identical gene mergers in human and canine cancers

Many cancers are said to be homologous in humans and dogs, so that a team from the Institute of Genetics and Development in Rennes is working to identify the genetic causes of these cancers, for the mutual benefit of both species. Its researchers have discovered in the dog chromosomal alterations inducing "fusions" of genes, well known and characteristic of certain lymphomas or sarcomas in humans. Publication in Cancer Research.

Montage : bouvier bernois et caryotype virtuel. Crédit images originales : Amage9 et By Jhagenk (talk) via Wikimedia Commons

The pet dog is unfortunately subject to many genetic diseases, often specific to breeds, including many cancers. On the other hand, it benefits from an excellent medical follow-up. These two characteristics make it a natural and spontaneous model that is increasingly relevant for the genetic and therapeutic study of cancers. Indeed, many cancers are "homologous" in humans and dogs, whether clinically, histopathologically or treatment responses.

In this context, the goal of the Rennes researchers is to identify the genetic causes of these cancers in dogs for mutual benefit.

Crédit : R. Ulvé, M. Rault et al.

[Continue reading on the site of l'INSB du CNRS]

Collaboration

To carry out this study, the authors of this article were assisted by veterinary practitioners, specialists in veterinary oncology and histopathology laboratories who provided samples or provided their clinical skills and expertise in veterinary oncology. The part of this work dealing with lymphoma was carried out in partnership with the company Biotrial, via the thesis of R. Ulvé, in CIFRE convention, within the framework of the "OncoTrial" Joint Laboratory created between Biotrial and Biosit, a mixed unit. of service in biology-health.

Complete list of units and institutions that collaborated studies.

Reference

Discovery of Human-Similar Gene Fusions in Canine Cancers
Ulvé R, Rault M, Bahin M, Lagoutte L, Abadie J, De Brito C, Coindre JM, Botherel N, Rousseau A, Wucher V, Cadieu E, Thieblemont C, Hitte C, Cornevin L, Cabillic F, Bachelot L, Gilot D, Hennuy B, Guillaudeux T, Le Goff A, Derrien T, Hédan B, André C.
Cancer Res. 2017 Sep 7. doi: 10.1158/0008-5472.CAN-16-2691.

Learn more

Article originally published on the website of the University of Rennes 1, October 30, 2017.

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