A new target for cancer therapy?

IGDR's researchers have demonstrated, using insect tumor stem cells, a new resistance mechanism in Aurora A mutants. These mutant cells continue to proliferate, even without a key mechanism called the spindle assembly checkpoint. These results, obtained in collaboration with the Institut Jacques Monod (University Denis Diderot-Paris 7) are published in Nature Communications.

>Full article available in French
Neuroblastes en cours de division : microtubules (faisceau mitotique) en vert, chromosomes en bleu. Crédit : Régis Giet


Reference et financing

Spindle assembly checkpoint inactivation fails to suppress neuroblast tumour formation in aurA mutant Drosophila
Renaud Caous, Aude Pascal, Pierre Romé, Laurent Richard-Parpaillon, Roger Karess & Régis Giet

Nature Communications 6, Article number: 8879
doi:10.1038/ncomms9879

The study was jointly funded by La Ligue Nationale Contre le Cancer , l’Association de la Recherche sur le Cancer, l'unité mixte de service Biosit and the University of Rennes 1 (France).

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