Two microtubule architectures are essential for the segregation of chromosomes in mitosis: the bipolar spindle (metaphase) and the central spindle (anaphase). We try to understand how are assembled these spindles with a particular focus on the central spindle.
We are also interested in the roles of the primary cilia: a cellular structure also assembled from microtubules but on quiescent cells, this cilia is disassembled when the cell enters a division cycle. Our projects are mainly focused on the study of post-translational modifications of proteins that regulate cell cycle progression, such as phosphorylation and ubiquitination. The team is also heavily involved in cancer research and ciliopathies.
We seek to understand how deregulation of cell cycle controls can contribute to cancer occurrence, progression, and resistance to treatment. We are looking for inhibitors of the cell cycle proteins to be used in cancer treatments.