Publications

> 2021

AhR and Cancer: From gene profiling to targeted therapy.
Paris A*, Tardif N*, Galibert MD, Corre S.
Int J Mol Sci. 2021 Jan 13;22(2):752. doi: 10.3390/ijms22020752. - * Equal contribution

 

> 2020

Human TYRP1: two functions for a single gene?
Gautron A, Migault M, Bachelot L, Corre S, Galibert MD, Gilot D.
Pigment Cell Melanoma Res. 2020 Dec 11. doi: 10.1111/pcmr.12951.

The powerful world of antisense oligonucleotides: From bench to bedside.
Quemener AM, Bachelot L, Forestier A, Donnou-Fournet E, Gilot D, Galibert MD.
Wiley Interdiscip Rev RNA. 2020 Sep;11(5):e1594. doi: 10.1002/wrna.1594. Epub 2020 Mar 31. - Journal Cover

PTPN11 mutations in canine and human disseminated histiocytic sarcoma.
Hédan B, Rault M, Abadie J, Ulvé R, Botherel N, Devauchelle P, Copie-Bergman C, Cadieu E, Parrens M, Alten J, Zalcman EL, Cario G, Damaj G, Mokhtari K, Le Loarer F, Coulomb-Lhermine A, Derrien T, Hitte C, Bachelot L, Breen M, Gilot D, Blay JY, Donadieu J, André C.
Int J Cancer. 2020 Sep 15;147(6):1657-1665. doi: 10.1002/ijc.32991. Epub 2020 Apr 8.

Involvement of caspase-1 in inflammasomes activation and bacterial clearance in S. aureus-infected osteoblast-like MG-63 cells.
Lima Leite E, Gautron A, Deplanche M, Nicolas A, Ossemond J, Nguyen MT, do Carmo FLR, Gilot D, Azevedo V, Götz F, Le Loir Y, Otto M, Berkova N.
Cell Microbiol. 2020 Aug;22(8):e13204. doi: 10.1111/cmi.13204. Epub 2020 Apr 6.

Role of Flavonoids in the Prevention of AhR-Dependent Resistance During Treatment with BRAF Inhibitors.
Leclair HM, Tardif N, Paris A, Galibert MD, Corre S.
Int J Mol Sci. 2020 Jul 16;21(14):5025. doi: 10.3390/ijms21145025.

Implementation of a molecular tumor board at a regional level to improve access to targeted therapy.
Bourien H, Lespagnol A, Campillo-Gimenez B, Felten-Vinot I, Metges JP, Corre R, Lesimple T, le Marechal C, Boussemart L, Kammerer-Jacquet SF, le Gall E, Denoual F, de Tayrac M, Galibert MD, Mosser J, Edeline J.
Int J Clin Oncol. 2020 Jul;25(7):1234-1241. doi: 10.1007/s10147-020-01661-6. Epub 2020 Mar 25.

Depicting the genetic architecture of pediatric cancers through an integrative gene network approach.
Savary C, Kim A, Lespagnol A, Gandemer V, Pellier I, Andrieu C, Pagès G, Galibert MD, Blum Y, de Tayrac M.
Sci Rep. 2020 Jan 27;10(1):1224. doi: 10.1038/s41598-020-58179-0.

 

> 2019

USF1 defect drives p53 degradation during Helicobacter pylori infection and accelerates gastric carcinogenesis.
Costa L, Corre S, Michel V, Le Luel K, Fernandes J, Ziveri J, Jouvion G, Danckaert A, Mouchet N, Da Silva Barreira D, Torres J, Camorlinga M, D'Elios MM, Fiette L, De Reuse H, Galibert MD*,
Touati E*. 
GUT. 2020 Sep;69(9):1582-1591. doi: 10.1136/gutjnl-2019-318640. Epub 2019 Dec 10.- * Equal contribution

Mechanisms of extramedullary relapse in acute lymphoblastic leukemia: Reconciling biological concepts and clinical issues. 
Gaudichon J, Jakobczyk H, Debaize L, Cousin E, Galibert MD, Troadec MB, Gandemer V. 
Blood Rev. 2019 Jul;36:40-56. doi: 10.1016/j.blre.2019.04.003. Epub 2019 Apr 17.

6-Formylindolo[3,2-b]carbazole (FICZ) is a Very Minor Photoproduct of Tryptophan at Biologically Relevant Doses of UVB and Simulated Sunlight.
Youssef A, von Koschembahr A, Caillat S, Corre S, Galibert MD, Douki T.
Photochem Photobiol. 2019 Jan;95(1):237-243. doi: 10.1111/php.12950. Epub 2018 Jul 12.

 

> 2018

Modulation of Bacterial sRNAs Activity by Epigenetic Modifications: Inputs from the Eukaryotic miRNAs.
Felden B, Gilot D. 
Genes (Basel). 2018 Dec 31;10(1):22. doi: 10.3390/genes10010022.

Sustained activation of the Aryl hydrocarbon Receptor transcription factor promotes resistance to BRAF-inhibitors in melanoma. 
Corre S*, Tardif N*, Mouchet N, Leclair HM, Boussemart L, Gautron A, Bachelot L, Perrot A, Soshilov A, Rogiers A, Rambow F, Dumontet E, Tarte K, Bessede A, Guillemin GJ, Marine JC, Denison MS, Gilot D*, Galibert MD*.
Nat Commun. 2018 Nov 14;9(1):4775. doi: 10.1038/s41467-018-06951-2. - * Equal contribution 

Interplay between transcription regulators RUNX1 and FUBP1 activates an enhancer of the oncogene c-KIT and amplifies cell proliferation. 
Debaize L*, Jakobczyk H*, Avner S, Gaudichon J, Rio AG, Sérandour AA, Dorsheimer L, Chalmel F, Carroll JS, Zörnig M, Rieger MA, Delalande O, Salbert G, Galibert MD, Gandemer V, Troadec MB.
Nucleic Acids Res. 2018 Nov 30;46(21):11214-11228. doi: 10.1093/nar/gky756. - * Equal contribution 

The master regulator FUBP1: its emerging role in normal cell function and malignant development.
Debaize L, Troadec MB.
Cell Mol Life Sci. 2019 Jan;76(2):259-281. doi: 10.1007/s00018-018-2933-6. Epub 2018 Oct 20.

 

> 2017

Promises and limitations of nanoparticles in the era of cell therapy: Example with CD19-targeting chimeric antigen receptor (CAR)-modified T cells.
Jakobczyk H, Sciortino F, Chevance S, Gauffre F, Troadec MB.
Int J Pharm. 2017 Nov 5;532(2):813-824. doi: 10.1016/j.ijpharm.2017.07.075. Epub 2017 Jul 29.

Discovery of Human-Similar Gene Fusions in Canine Cancers.
Ulvé R, Rault M, Bahin M, Lagoutte L, Abadie J, De Brito C, Coindre JM, Botherel N, Rousseau A, Wucher V, Cadieu E, Thieblemont C, Hitte C, Cornevin L, Cabillic F, Bachelot L, Gilot D, Hennuy B, Guillaudeux T, Le Goff A, Derrien T, Hédan B, André C.
Cancer Res. 2017 Nov 1;77(21):5721-5727. doi: 10.1158/0008-5472.CAN-16-2691. Epub 2017 Sep 7.

A non-coding function of TYRP1 mRNA promotes melanoma growth.
Gilot D*, Migault M*, Bachelot L, Journé F, Rogiers A, Donnou-Fournet E, Mogha A, Mouchet N, Pinel-Marie ML, Mari B, Montier T, Corre S, Gautron A, Rambow F, El Hajj P, Ben Jouira R, Tartare-Deckert S, Marine JC, Felden B, Ghanem G, Galibert MD.
Nat Cell Biol. 2017 Nov;19(11):1348-1357. doi: 10.1038/ncb3623. Epub 2017 Oct 9. - * Equal contribution 

Optimization of proximity ligation assay (PLA) for detection of protein interactions and fusion proteins in non-adherent cells : application to pre-B lymphocytes.
Debaize L, Jakobczyk H, Rio AG, Gandemer V, Troadec MB.
Mol Cytogenet. 2017 Jul 20;10:27. doi: 10.1186/s13039-017-0328-2. eCollection 2017.

Do the Side Effects of BRAF Inhibitors Mimic RASopathies?
Sfecci A, Dupuy A, Dinulescu M, Droitcourt C, Adamski H, Hadj-Rabia S, Odent S, Galibert MD, Boussemart L.
J Invest Dermatol. 2017 Apr;137(4):805-809. doi: 10.1016/j.jid.2016.12.012.

Definition and identification of small RNA sponges: Focus on miRNA sequestration.
Migault M, Donnou-Fournet E, Galibert MD, Gilot D.
Methods. 2017 Mar 15;117:35-47. doi: 10.1016/j.ymeth.2016.11.012. Epub 2016 Nov 19.

 

> 2016

Integrating targeted gene expression and a skin model system to identify functional inhibitors of the UV activated p38 MAP kinase.
Abrahams A, Mouchet N, Gouault N, Lohézic Le Dévéhat F, Le Roch M, Rouaud I, Gilot D, Galibert MD.
Photochem Photobiol Sci. 2016 Nov 30;15(12):1468-1475. doi: 10.1039/c6pp00283h.

 

> 2015

CD9, a key actor in the dissemination of lymphoblastic leukemia, modulating CXCR4-mediated migration via RAC1 signaling.
Arnaud MP, Vallée A, Robert G, Bonneau J, Leroy C, Varin-Blank N, Rio AG, Troadec MB, Galibert MD and Gandemer V.
Blood. 2015 Oct 8;126(15):1802-12. doi: 10.1182/blood-2015-02-628560. Epub 2015 Aug 28.

Prognostic and predictive values of oncogenic BRAF, NRAS, c-KIT and MITF in cutaneous and mucous melanoma. 
Pracht M*, Mogha A*, Lespagnol A, Fautrel A, Mouchet N, Le Gall F, Paumier V, Lefeuvre-Plesse C, Rioux-Leclerc N, Mosser J, Oger E, Adamski H, Galibert MD*, Lesimple T*.
J Eur Acad Dermatol Venereol. 2015 Aug;29(8):1530-8. doi: 10.1111/jdv.12910. Epub 2015 Jan 26. - * Equal contribution 

SNPs at miR-155 binding sites of TYRP1 explain discrepancy between mRNA and protein and refine TYRP1 prognostic value in melanoma. 
El Hajj P, Gilot D, Migault M, Theunis A, van Kempen LC, Salés F, Fayyad-Kazan H, Badran B, Larsimont D, Awada A, Bachelot L, Galibert MD, Ghanem G, Journe F.
Br J Cancer. 2015 Jun 30;113(1):91-8. doi: 10.1038/bjc.2015.194. Epub 2015 Jun 11.

Follow-up of post-transplant minimal residual disease and chimerism in childhood lymphoblastic leukaemia: 90 d to react.
Pochon C, Oger E, Michel G, Dalle J, Salmon A, Nelken B, Bertrand Y, Cavé H, Cayuela J, Grardel N, Macintyre E, Margueritte G, Méchinaud F, Rohrlich P, Paillard C, Demeocq F, Schneider P, Plantaz D, Poirée M, Eliaou J, Semana G, Drunat S, Jonveaux P, Bordigoni P, Gandemer V.
Br J Haematol. 2015 Apr;169(2):249-61. doi: 10.1111/bjh.13272. Epub 2014 Dec 19.

 

> 2014

CDK/CK1 inhibitors roscovitine and CR8 downregulate amplified MYCN in neuroblastoma cells. 
Delehouzé C, Godl K, Loaëc N, Bruyère C, Desban N, Oumata N, Galons H, Roumeliotis TI, Giannopoulou EG, Grenet J, Twitchell D, Lahti J, Mouchet N, Galibert MD, Garbis SD, Meijer L.
Oncogene. 2014 Dec 11;33(50):5675-87. doi: 10.1038/onc.2013.513. Epub 2013 Dec 9.

Comparative transcriptional profiling of human Merkel cells and Merkel cell carcinoma. 
Mouchet N, Coquart N, Lebonvallet N, Le Gall-Ianotto C, Mogha A, Fautrel A,Boulais N, Dréno B, Martin L, Hu W, Galibert MD, Misery L.
Exp Dermatol. 2014 Dec;23(12):928-30. doi: 10.1111/exd.12546. Epub 2014 Nov 11.

Skin cancer, photoprotection, and skin of color. 
Dadzie OE, Jablonski NG, Mahalingam M, Dupuy A, Petit A.
J Am Acad Dermatol. 2014 Sep;71(3):586. doi: 10.1016/j.jaad.2014.04.071.

Aryl hydrocarbon receptor control of a disease tolerance defense pathway. 
Bessede A, Gargaro M, Pallotta MT, Matino D, Servillo G, Brunacci C, Bicciato S, Mazza E, Macchiarulo A, Vacca C, Iannitti R, Tissi L, Volpi C, Belladonna ML, Orabona C, Bianchi R, Lanz T, Platten M, Della Fazia MA, Piobbico D, Zelante T, Funakoshi H, Nakamura T, Gilot D, Denison MS, Guillemin GJ, DuHadaway JB, Prendergast GC, Metz R, Geffard M, Boon L, Pirro M, Iorio A, Veyret B, Romani L, Grohmann U, Fallarino F & Puccetti P.
Nature. 2014 Jul 10;511(7508):184-90. doi: 10.1038/nature13323.

AhR and Arnt differentially regulate NF-κB signaling and chemokine responses in human bronchial epithelial cells. 
Øvrevik J, Låg M, Lecureur V, Gilot D, Lagadic-Gossmann D, Refsnes M, Schwarze PE, Skuland T, Becher R & Holme JA.
Cell Commun Signal. 2014 Jul 24;12:48. doi: 10.1186/s12964-014-0048-8.

p53 requires the stress sensor USF1 to direct appropriate cell fate decision. 
Bouafia A, Corre S, Gilot D, Mouchet N, Prince S & Galibert MD.
PLoS Genet. 2014 May 15;10(5):e1004309. doi: 10.1371/journal.pgen.1004309. eCollection 2014.

Clinical value of pre-transplant minimal residual disease in childhood lymphoblastic leukaemia: the results of the French minimal residual disease-guided protocol. 
Gandemer V, Pochon C, Oger E, Dalle JH, Michel G, Schmitt C, de Berranger E, Galambrun C, Cavé H, Cayuela JM, Grardel N, Macintyre E, Margueritte G, Méchinaud F, Rorhlich P, Lutz P, Demeocq F, Schneider P, Plantaz D, Poirée M, Bordigoni P.
Br J Haematol. 2014 May;165(3):392-401. doi: 10.1111/bjh.12749. Epub 2014 Jan 30.

Testing chemical carcino genicity by using a transcriptomics HepaRG-based model ? 
Doktorova TY, Yildirimman R, Ceelen L, Vilardell M, Vanhaecke T, Vinken M, Ates G, Heymans A, Gmuender H, Bort R, Corvi R, Phrakonkham P, Li R, Mouchet N, Chesne C, van Delft J, Kleinjans J, Castell J, Herwig R, Rogiers V.
EXCLI J. 2014 May 28;13:623-37. eCollection 2014.

Naturally occurring melanomas in dogs as models for non-UV pathways of human melanomas. 
Gillard M, Cadieu E, De Brito C, Abadie J, Vergier B, Devauchelle P, Degorce F, Dréano S, Primot A, Dorso L, Lagadic M, Galibert F, Hédan B, Galibert MD, André C.
Pigment Cell Melanoma Res. 2014 Jan;27(1):90-102. doi: 10.1111/pcmr.12170. Epub 2013 Nov 1.Journal cover 

 

> 2013

Cutaneous melanoma in patients treated with tumour necrosis factor inhibitors: a retrospective series of 15 patients. 
Chabbert C, Adamski H, Guillet G, Sassolas B, Misery L, Perrinaud A, Machet L, Quereux G, Esteve E, Solau-Gervais E, Saraux A, Polard E, Lesimple T, Le Gall F, Dreno B, Dupuy A.
J Eur Acad Dermatol Venereol. 2014 Nov;28(11):1540-4. doi: 10.1111/jdv.12347. Epub 2013 Dec 13.

Vemurafenib-induced eccrine squamous syringometaplasia. 
Lescoat A, Droitcourt C, Stock N, Le Gall F, Dupuy A.
Dermatology. 2013;226(4):362-4. doi: 10.1159/000351320. Epub 2013 Jul 13.

Breakpoint-specific multiplex polymerase chain reaction allows the detection of IKZF1 intragenic deletions and minimal residual disease monitoring in B-cell precursor acute lymphoblastic leukemia.
Caye A, Beldjord K, Mass-Malo K, Drunat S, Soulier J, Gandemer V, Baruchel A, Bertrand Y, Cavé H, Clappier E.
Haematologica. 2013 Apr;98(4):597-601. doi: 10.3324/haematol.2012.073965. Epub 2012 Oct 12.

Tyrosinase-related protein 1 mRNA expression in lymph node metastases predicts overall survival in high-risk melanoma patients. 
El Hajj P, Journe F, Wiedig M, Laios I, Salès F, Galibert MD, Van Kempen LC, Spatz A, Badran B, Larsimont D, Awada A, Ghanem G.
Br J Cancer. 2013 Apr 30;108(8):1641-7. doi: 10.1038/bjc.2013.115. Epub 2013 Mar 21.

Aurora-a is involved in central spindle assembly through phosphorylation of ser 19 in p150glued. 
Reboutier D*, Troadec MB*, Cremet JY, Chauvin L, Guen V, Salaun P, Prigent C.
J Cell Biol. 2013 Apr 1;201(1):65-79. doi: 10.1083/jcb.201210060. - * Equal contribution

 

> 2012

Excellent prognosis of late relapses of ETV6/RUNX1-positive childhood acute lymphoblastic leukemia: lessons from the FRALLE 93 protocol.
Gandemer V, Chevret S, Petit A, Vermylen C, Leblanc T, Michel G, Schmitt C, Lejars O, Schneider P, Demeocq F, Bader-Meunier B, Bernaudin F, Perel Y, Auclerc MF, Cayuela JM, Leverger G, Baruchel A - FRALLE Group.
Haematologica. 2012 Nov;97(11):1743-50. doi: 10.3324/haematol.2011.059584. Epub 2012 May 11.

The epithelial-mesenchymal transition (EMT) regulatory factor SLUG (SNAI2) is a downstream target of SPARC and AKT in promoting melanoma cell invasion. 
Fenouille N, Tichet M, Dufies M, Pottier A, Mogha A, Soo JK, Rocchi S, Mallavialle A, Galibert MD, Khammari A, Lacour JP, Ballotti R, Deckert M, Tartare-Deckert S.
PLoS One. 2012;7(7):e40378. doi: 10.1371/journal.pone.0040378. Epub 2012 Jul 20.

Presence of putative stem cells in Merkel cell carcinomas. 
Lemasson G, Coquart N, Lebonvallet N, Boulais N, Galibert MD, Marcorelles P, Misery L.
J Eur Acad Dermatol Venereol. 2012 Jun;26(6):789-95. doi: 10.1111/j.1468-3083.2011.04132.x. Epub 2011 May 25.

Nucleophosmin/b23 activates aurora-a at the centrosome through phosphorylation of serine 89. 
Reboutier D*, Troadec MB*, Crémet JY, Fukasawa K, Prigent C.
J Cell Biol. 2012 Apr 2;197(1):19-26. doi: 10.1083/jcb.201107134. Epub 2012 Mar 26. - * Equal contribution

USF-1 is critical for maintaining genome integrity in response to UV-induced DNA photolesions. 
Baron Y*, Corre S*, Mouchet N, Vaulont S, Prince S, Galibert MD.
PLoS Genet. 2012 Jan;8(1):e1002470. doi: 10.1371/journal.pgen.1002470. Epub 2012 Jan 26. - * Equal contribution

 

> 2011

TYRP1 mRNA expression in melanoma metastases correlates with clinical outcome.
Journe F, Id Boufker H, Van Kempen L, Galibert MD, Wiedig M, Salès F, Theunis A, Nonclercq D, Frau A, Laurent G, Awada A, Ghanem G.
Br J Cancer. 2011 Nov 22;105(11):1726-32. doi: 10.1038/bjc.2011.451. Epub 2011 Nov 1.

Overexpression of active Aurora-C kinase results in cell transformation and tumour formation. 
Khan J, Ezan F, Crémet JY, Fautrel A, Gilot D, Lambert M, Benaud C, Troadec MB, Prigent C.
PLoS One. 2011;6(10):e26512. doi: 10.1371/journal.pone.0026512. Epub 2011 Oct 27.

Targeted deletion of the mouse mitoferrin1 gene : from anemia to porphyria. 
Troadec MB, Warner D, Wallace J, Thomas KR, Spangrude GJ, Phillips J, Khalimonchuk O, Paw BH, McVey Ward D, Kaplan J.
Blood. 2011 May 19;117(20):5494-502. doi: 10.1182/blood-2010-11-319483. Epub 2011 Feb 10. - Journal Cover

Identification of distal cis-regulatory elements at the mouse mitoferrin loci using zebrafish transgenesis.
Amigo JD, Ming Yu, Troadec MB, Gwynn B, Cooney JD, Lambert AJ, Chi NC, Weiss MJ, Peters LL, Kaplan J, Cantor AB, Paw BH.
Mol Cell Biol. 2011 Apr;31(7):1344-56. doi: 10.1128/MCB.01010-10. Epub 2011 Jan 19. - Journal Cover

Inorganic arsenic alters expression of immune and stress response genes in activated primary human T lymphocytes. 
Martin-Chouly C, Morzadec C, Bonvalet M, Galibert MD, Fardel O, Vernhet L.
Mol Immunol. 2011 Mar;48(6-7):956-65. doi: 10.1016/j.molimm.2011.01.005. Epub 2011 Feb 1.

RNAi-based screening identifies kinases interfering with dioxin-mediated up-regulation of CYP1A1 activity. 
Gilot D, Le Meur N, Giudicelli F, Le Vée M, Lagadic-Gossmann D, Théret N, Fardel O.
PLoS One. 2011 Mar 29;6(3):e18261. doi: 10.1371/journal.pone.0018261.

A 4-gene signature associated with clinical outcome in high-grade gliomas.
de Tayrac M, Aubry M, Saïkali S, Etcheverry A, Surbled C, Guénot F, Galibert MD, Hamlat A, Lesimple T, Quillien V, Menei P, Mosser J.
Clin Cancer Res. 2011 Jan 15;17(2):317-27. doi: 10.1158/1078-0432.CCR-10-1126. Epub 2011 Jan 11.

 

> 2010

Merkel cell polyomavirus small T antigen mRNA level is increased following in vivo UV-radiation. 
Mogha A, Fautrel A, Mouchet N, Guo N, Corre S, Adamski H, Watier E, Misery L, Galibert MD.
PLoS One. 2010 Jul 2;5(7):e11423. doi: 10.1371/journal.pone.0011423.

In vivo identification of solar radiation-responsive gene network: role of the p38 stress-dependent kinase. 
Mouchet N, Adamski H, Bouvet R, Corre S, Courbebaisse Y, Watier E, Mosser J, Chesné C, Galibert MD.
PLoS One. 2010 May 21;5(5):e10776. doi: 10.1371/journal.pone.0010776.

CD9 expression can be used to predict childhood TEL/AML1-positive acute lymphoblastic leu kemia: Proposal for an accelerated diagnostic flowchart. 
Gandemer V, Aubry M, Roussel M, Rio AG, de Tayrac M, Vallée A, Mosser J, Ly-Sunnaram B, Galibert MD.
Leuk Res. 2010 Apr;34(4):430-7. doi: 10.1016/j.leukres.2009.09.033. Epub 2009 Nov 5.

ERK-regulated differential expression of the Mitf 6a/b splicing isoforms in melanoma. 
Primot A, Mogha A, Corre S, Roberts K, Debbache J, Adamski H, Dreno B, Khammari A, Lesimple T, Mereau A, Goding CR, Galibert MD.
Pigment Cell Melanoma Res. 2010 Feb;23(1):93-102. doi: 10.1111/j.1755-148X.2009.00652.x. Epub 2009 Nov 6.

BOOK CHAPTERS

Identification of Specific Protein/E-Box-Containing DNA Complexes: Lessons from the Ubiquitously Expressed USF Transcription Factors of the b-HLH-LZ Super Family. 
Galibert MD, Baron Y.
Methods Mol Biol. 2010.
In: "Transcription Factors: Methods and Protocols", (ed. Higgins Paul J). Springer, Humana Press, USA, 2010. - 647:391-406.

In Vivo and In Vitro Tools to Identify and Study Transcriptional Regulation of USF-1 
Galibert MD, Corre S.
Methods Mol Biol. 2010.
In: "Transcription Factors: Methods and Protocols", (ed. Higgins Paul J). Springer, Humana Press, USA, 2010. - 647:339-355.