The IGDR is deeply engaged in conceiving innovative and multidisciplinary approaches towards a quantitative and dynamic understanding of life. Its research revolves around 3 main scientific themes involving several scientific questions from basic to translational research:
- From molecule to cell : structure versus dynamics
Discover how the structure impacts the function of a molecule or a complex of several molecules, and how the plastic network of actors / proteins in dynamic interaction reflects the robustness of an organelle or a cell.
- From cell to organism : an identity case
Understand how a single cell gives rise to a whole organism, formed by the interplay of hundreds of different cell types that interact with each other while adapting to external constraints.
- From genes to cancer and genetic diseases
Find genetic predispositions and alterations of causality and understand their individual and cooperative impacts in the genesis and development of genetic diseases. How does a cell become cancerous? How can we detect it and how can we eliminate it?
Specific deseases that we study
Several diseases are very specifically studied by our research teams as :
- Acute lymphoblastic leukemia B: Virginie GANDEMER in Marie-Dominique GALIBERT Group
- Ciliopathies: Claude PRIGENT Group
- Cohesinopathies: Erwan WATRIN in Claude PRIGENT Group
- Diseases linked to dog genetics: Catherine ANDRÉ Group
- Glioma: Jean MOSSER Group
- Hemochromatosis: Jean MOSSER Group
- Holoprosencephaly: Véronique DAVID Group
- Infertility: Guillaume HALET Group
- Kidney Cancer: Yannick ARLOT Group
- Melanoma: Marie-Dominique GALIBERT Group
- Myopathies: Jean-François HUBERT Group
- Hereditary skin diseases : Luc PAILLARD Group
Research at the crossroads of knowledge
Multidisciplinarity is among the scientific priorities of the Institute. The IGDR indeed encourages the development of several scientific fields such as translational research, structural biology, mechanotransduction, simulation, quantitative biology or microfluidics.