Research M3PE

EPITHELIAL POLARITY MAINTENANCE AND MEMBRANE TRAFFICKING

The intestine performs one of the most essential functions of an animal organism, food absorption. We investigate three key aspects of the making of an intestine:

- Dynamics of the absorptive apical membrane

Control of intestinal cell proliferation and terminal differentiation

Coordinated intestinal morphogenesis

To answer these questions, we undertake a multiscale approach, from molecules to whole organism, using C. elegans as a model organism and intestinal organoids a mammalian non-animal model. Moreover, our collaborations with physicians allow us to address the clinical relevance of our discoveries. Our main tools are cutting-edge microscopy (Zeiss Airyscan, Random illumination Microscopy, laser nanoablations), and advanced genetic methods (endogenously tagged genes, time-/tissue-specific degrons, gene editing).