Catherine ANDRÉ Group

Canine genetics

Catherine ANDRÉ

Group leader

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> Phone: +33 (0)2 23 23 45 09

To date, about 500 genetic diseases have been identify in the dog species. This diseases are spontaneous, breed specific with a high incidence in the affected breeds. In addition, most of them are homologous to human diseases. In this context, considerind dog as a patient, our research projects aim to the identification of the genetic basis of diseases affected both dogs and humans, with mutual genetic and therapeutic interest in both species.

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Major publications

Selected Publications

  • Ronan Ulvé, Mélanie Rault, Mathieu Bahin,Laetitia Lagoutte, Jérôme Abadie, Clotilde De Brito, Jean-Michel Coindre,Nadine Botherel, Audrey Rousseau, Valentin Wucher, Edouard Cadieu, Catherine Thieblemont, Christophe Hitte, Laurence Cornevin, Florian Cabillic, Laura Bachelot, David Gilot, Benoit Hennuy, Thierry Guillaudeux, Arnaud Le Goff, Thomas Derrien, Benoît Hédan and Catherine André. Discovery of Human-Similar Gene Fusions in Canine Cancers. Cancer Research, 2017 Oct 9.

    Broeckx BJG, Derrien T, Mottier S, Wucher V, Cadieu E, Hédan B, Le Béguec C, Botherel N, Lindblad-Toh K, Saunders JH, Deforce D, André C, Peelman L, Hitte C. An exome sequencing based approach for genome-wide association studies in the dog. Scientific Reports. 2017 Nov 15.

    Plassais J, Guaguère E, Lagoutte L, Guillory AG, Dufaure de Citres C, Degorce-Rubiales F, Delverdier M, Vaysse A, Quignon P, Bleuart C, Hitte C, Fautrel A, Kaerle C, Bellaud P, Bensignor E, Queney G, Bourrat E, Thomas A* and André C*. A spontaneous KRT16 mutation in a dog breed: a model for human Focal Non Epidermolytic Palmoplantar Keratoderma (FNEPPK). J Invest Dermatol. 2015 Apr;135(4):1187-90.

    Gillard M*, Cadieu E*, De Brito C, Abadie J, Vergier B, Devauchelle P, Degorce F, Dreano S, Primot A, Dorso L, Lagadic M, Galibert F, Hédan B, Galibert MD, and André C. Naturally occurring melanomas in dogs as relevant models for human melanomas. Pigment Cell & Melanoma Research 2014, 2014 Jan;27(1):90-102.

    Grall A, Guaguère E, Planchais S, Grond S, Bourrat E, Hausser I, Hitte C, Le Gallo M, Derbois C, Kim GJ, Lagoutte L, Degorce-Rubiales F, Radner FP, Thomas A, Kury S, Bensignor E, Fontaine J, Pin D, Zimmermann R, Zechner R, Lathrop M, Galibert F, André C, Fischer J. PNPLA1 mutations cause autosomal récessive congenital ichthyosis in golden retriever dogs and humans. Nat Genet. 2012 Jan15;44(2):140-7.

    Derrien T, Vaysse A, André C, Hitte C. Annotation of the domestic dog genome sequence: finding the missing genes. Mamm Genome. 2012 Feb;23(1-2):124-31.


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