Christophe HITTE

Information

Research Support

Catherine ANDRÉ Group

+33 (0)2 23 23 47 77

Villejean campus / Building 4 / Room 212

Responsibilities

‣ Scientific committee member of France Genomique. Since 2012
‣ Scientific committee member of ANR, France. Genomics, genetics, bioinformatics and system biology, 2011, 2012 & 2013. 

‣  Scientific committee member of AERES, 2014. 

‣ Academic Editor of BMC Veterinary Research. since 2011
‣ Expert of research grants and scientific projects for FP7-people-COFUND programme 2013-2018.

‣ Committee member of Thesis and HDR 

‣  Scientific committee member of the Animal Genetics Division of INRA (French National Institute for Agricultural Research). 2017-2020

‣ Scientific committee member of plate-forme Bioinformatique, Rennes, Genouest, 2006-now 

Education

  • Master in Bioinformatics: University Rennes1, France: Statistics for biology; Comparative Genomics; Genome Organization and genetic polymorphim.
  • Master in Bioinformatics: University Rouen, France: Comparative Genomics; Genome Mapping

In a few words

My research areas are: 
Genome  Annotation - Non-coding genome analysis - NGS Analysis- Molecular genetics of cancer - Directional Selection identification - Canids evolution - Paleogenetics and Ancient DNA analyse 


Scientific Program & Consortium member of:

  • International consortium:  Natural Environmental Research Council –NERC- , « Deciphering dog domestication through a combined ancient DNA and geometric morphometric approach » (2013-2016). PI : Dr G. Larson (Durham University).
  • Project « MOLoSSE : ModeLisation statistique de la dépendance dans les études d’association génétiques à l’échelle du génome GWAS ». (2012-213). Projets Exploratoires Pluridisciplinaires –PEPS-, Biology, Mathematics & Informatics. PI, Dr. M. Emily (IRMAR, Agrocampus, Rennes).
  • International consortium of canine genetics– LUPA- 7th PCRD. PI - Dr. K. Lindblad-Toh, Dr. M. Georges. 2008-2012.
  • Project « PERCIMAP : Construction of a high-density Tilapia RH map » (2008-2009). Project ANR genomics. PI: Dr. Catherine Ozouf.
  • European project AquaFirst : Développement d’outils génomiques pour les modèles Dorade et Bar : construction et validation de cartes d’hybrides irradiés, période 2005-2008. Project FP7. PI: Dr. Patrick Prunet.

Major publications

  • Wucher V, Legeai F, Hédan B, Rizk G, Lagoutte L, Leeb T, Jagannathan V, Cadieu E, David A, Lohi H, Cirera S, Fredholm M, Botherel N, Leegwater PA, Le Béguec C, Fieten H, Johnson J, Alföldi J, André C, Lindblad-Toh K, Hitte C, Derrien T. FEELnc: a tool for long non-coding RNA annotation and its application to the dog transcriptome. Nucleic Acids Res., 2017. PMID: 28053114

    Frantz LA, Mullin VE, Pionnier-Capitan M, Lebrasseur O, Ollivier M, Perri A, Linderholm A, Mattiangeli V, Teasdale MD, Dimopoulos EA, Tresset A, Duffraisse M, McCormick F, Bartosiewicz L, Gál E, Nyerges ÉA, Sablin MV, Bréhard S, Mashkour M, Bălăşescu A, Gillet B, Hughes S, Chassaing O, Hitte C, Vigne JD, Dobney K, Hänni C, Bradley DG, Larson G. Genomic and archaeological evidence suggest a dual origin of domestic dogs. Science. 2016.

    Vaysse A, Ratnakumar A, Derrien T, Axelsson E, Pielberg GR, Sigurdsson S, Fall T, Seppälä E, Hansen MST, Lawley CT, Karlsson EK, The LUPA consortium, Bannasch D, Vilà C, Lohi H, Galibert F, Fredholm M, Hedhammar A, André C, Lindblad-Toh K, Hitte C and Webster MT. Identification of genomic regions associated with phenotypic variation between dog breeds using selection mapping. PLos Genetics. 2011.

    Abitbol M, Thibaud JL, Olby N, Hitte C, Puech JP, Hédan B, Dréano S, Brahimi S, Uriarte A, Delattre D, Bernex F, André C, Gray F, Delisle F, Caillaud C, Panthier JJ, Aubin-Houzelstein G, Blot S, Tiret L. A canine Arylsulfatase G (ARSG) mutation leading to a sulfatase defiency is associated with neuronal ceroid lipofuscinosis. Proc. Natl. Acad. Sci. USA. 2010.

    Derrien T, André C, Galibert F, Hitte C. AutoGRAPH: an interactive web server for automating and visualizing comparative genome maps. Bioinformatics 2007.

    Hitte C, Madeoy J, Kirkness EF, Priat C, Lorentzen TD, Senger F, Thomas D, Derrien T, Ramirez C, Scott C, Evanno G, Pullar B, Cadieu E, Oza V, Lourgant K, Jaffe DB, Tacher S, Dreano S, Berkova N, Andre C, Deloukas P, Fraser C, Lindblad-Toh K, Ostrander EA, Galibert F. Facilitating genome navigation: survey sequencing and dense radiation-hybrid gene mapping. Nature Review Genetics. 2005.

    Lindblad-Toh K, coll…., Hitte C, Kim L, Koepfli KP, Parker HG, Pollinger JP, Searle SM, Sutter NB, Thomas R, Webber C, Broad Sequencing Team, Lander ES. Genome sequence, comparative analysis and haplotype structure of the domestic dog. Nature 2005.

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