Frédérique BARLOY-HUBLER

Information

Staff scientist

Catherine ANDRÉ Group

+33 (0)2 23 23 45 10

Villejean campus / Building 4 / Room 222/2

Responsibilities

2012-2017 Leader of  Biosit Amadeus bioinformatics Platform – UMR3480

2006-2011 Leader of B@sic bioinformatics team - UMR6026

2001-2006 Leader of  Sinorhizobium meliloti Genomics team - UMR6061                     

2006-2011 Deputy Director of Biosit IFR140

Education

Annotation of genes and genomes-ongoing training

In a few words

I am an Agronomic engineer, doctor in molecular biology and microbiology and researcher at CNRS since 2000.

I'm specialized, since the 90s, in in silico analysis of genomic sequences. My goals are to understand the genetic basis of phenotypic variability of organisms, in the contexts of medical, agricultural and industrial applications (functional genomics), to study the organization and the evolution of genes and genomes, to predict their function and their history (comparative genomic) and to manage and share these results and approaches in development dedicated computer tools.

After leading a team dedicated to microbial genomics and another one dedicated to applied bioinformatics (between 2000 and 2011), I led an academic expertise platform in genomes and microbiomes annotation (between 2011 and 2017).

Since January 2017, I joined the group of Catherine André to develop a project to understand the impact of the microbiota on development of mammal’s common diseases, especially cancers like melanoma or sarcoma.

My research areas included: 

  • Metagenomic studies (e.g. microbiota/ microbiome)
  • Genome assembly, gene-finding & annotation
  • Functional modeling & prediction

Major publications

  • Sandrine Le Gall-David, Vincent Meuric, Gaëlle Benzoni, Sophie Valière, Alain Guyonvarch, Jacques Minet, Martine Bonnaure-Mallet, Frédérique Barloy-Hubler. Effect of Zeolite on Small Intestine Microbiota of Broiler Chickens: A Case Study. Food and Nutrition Sciences 2017. Vol.8 No.1.          

    Brawand D, Wagner CE, Li YI, Malinsky M, Keller I, Fan S, Simakov O, Ng AY, Lim ZW, Bezault E, Turner−Maier J, Johnson J, Alcazar R, Noh HJ, Russell P, Aken B, Alföldi J, Amemiya C, Azzouzi N, Baroiller JF, Barloy-Hubler F, …, Di Palma F. The genomic substrate for adaptive radiation in African cichlid fish. Nature. 2014 : 18;513(7518):375−81.

    Nicolas A, Lucchetti-Miganeh C,  Ben Yaou R, Kaplan JC, Chelly J, Leturcq  F, Barloy-Hubler F, Le Rumeur E. Assessment of the structural and functional impact of in-frame mutations of the DMD gene, using the tools included in the eDystrophin online database. Orphanet Journal of Rare Diseases. 2012 : Jul 9;7:45·

    Lucchetti-Miganeh C, Goudenège D, Thybert D, Salbert G, Barloy-Hubler F. SORGOdb: Superoxide Reductase Gene Ontology curated DataBase. BMC Microbiology. 2011 : May 16;11:105.

    Goudenège D, Avner S, Lucchetti-Miganeh C, Barloy-Hubler F. CoBaltDB: Complete bacterial and archaeal orfeomes subcellular localization database and associated resources. BMC Microbiology 2010 Mar 23;10:88.

    Thybert D, Avner S, Lucchetti-Miganeh C, Chéron A, Barloy-Hubler F. OxyGene: an innovative platform for investigating oxidative-response genes in whole prokaryotic genomes. BMC Genomics. 2008 Dec 31;9:637.

    Sevin EW, Barloy-Hubler F. RASTA-Bacteria: a web-based tool for identifying toxin-antitoxin loci in prokaryotes. Genome Biol. 2007;8(8):R155.

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