Stéphanie LE BRAS

Information

Research professor

Claude PRIGENT Group

+33 2 23 23 43 45

Villejean Campus / Building 4 / Room 334

Responsibilities

  • Elected member of the Section 22 in the National Scientific Research Committee

Education

  • "Molecular and fundamental genetics", Bachelor’s degree in Molecular and Cellular Sciences and Biology of Organisms, University of Rennes1
  • "Genetics and cell biology", Master’s degree in Cellular and Molecular Life Science, University of Rennes1

Shared responsibilities

  • Air Liquide contact to order gaz

In a few words

After training in developmental biology and genetics, Stéphanie LE BRAS prepared her thesis at Pasteur Institute where she studied the DDK syndrome in Charles Babinet’s unit. She then did her post-doctorate in the team of Mark Van Doren at Johns Hopkins University in Baltimore, US where she became interested in the development of germline stem cell niche in Drosophila.

In 2007 she was recruited as an assistant professor in Roland LE BORGNE team where she characterized cellular mechanisms regulating Notch signaling pathway, which controls cell fate acquisition during the asymmetric division of sensory organs in Drosophila. In 2015, she joined the team of Claude PRIGENT where she study the role of Aurora A in symmetric and asymmetric cell division in Drosophila.

Major publications

  • Genetic identification of intracellular trafficking regulators involved in Notch-dependent binary cell fate acquisition following asymmetric cell division
    Le Bras S#, Rondanino C, Kriegel-Taki G, Dussert A and Le Borgne R#. # co.corresponding author
    Journal of Cell Science. 125, 4886-4901. 2012

    Development of the male germline stem cell niche in Drosophila
    Le Bras S and Van Doren M.
    Delopmental biology. 294, 92-103. 2006

    The murine ortholog of Notchless, a direct regulator of the Notch pathway in Drosophila, is essential for survival of Inner Cell Mass in blastocyst
    Cormier S*, Le Bras S*, Souilhol C, Vandormael-Pournin S, Durand B, Babinet C, Baldacci P, Cohen-Tannoudji M. * premiers co-auteurs
    Molecular and Cellular Biology. 26(9), 3541-9.  2006

    Transcript map of the Ovum mutant (Om) locus: isolation by exon-trapping of new candidates for the DDK syndrome
    Le Bras S, Cohen-Tannoudji M, Guyot V, Vandormael-Pournin S, Coumailleau F, Babinet C and Baldacci P.
    Gene. 296, 75-86. 2002

    BALB/c alleles at modifier loci increase the severity of the maternal effect of the “DDK syndrome
    Le Bras S, Cohen-Tannoudji M, Kress C, Vandormael-Pournin S, Babinet C and Baldacci P.
    Genetics. 154, 803-811. 2000

     

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