Vincent GUEN

Information

Staff scientist

Claude PRIGENT Group

+33 2 23 23 63 22

Institut de Génétique et Développement de Rennes (IGDR)
UMR 6290 IGDR - CNRS / Université de Rennes 1
Faculté de Médecine - Bat 4 - Etage 3 - 320
2 - AVE du Pr. Léon Bernard - CS 34317 - 35043 - RENNES CEDEX

 

Major publications

  • EMT programs promote basal mammary stem cell and tumor-initiating cell stemness by inducing primary ciliogenesis and Hedgehog signaling
    Guen VJ, Chavarria TE, Kröger C, Ye X, Weinberg RA, Lees JA.
    Proc Natl Acad Sci U S A. 2017 In press.

    A homozygous deleterious CDK10 mutation in a patient with agenesis of corpus callosum, retinopathy, and deafness.
    Guen VJ, Edvardson S, Fraenkel ND, Fattal-Valevski A, Jalas C, Anteby J, Shaag A, Dor T, Gillis D, Kerem E, Lees JA, Colas P, Elpeleg O.
    American Journal of Medical Genetics. 2017 In press.

    The awakening of the CDK10/Cyclin M protein kinase.
    Guen VJ, Gamble C, Lees JA, Colas P.
    Oncotarget. 2017 Jul 25;8(30):50174-50186.

    STAR syndrome-associated CDK10/Cyclin M regulates actin network architecture and ciliogenesis.
    Guen VJ, Gamble C, Perez DE, Bourassa S, Zappel H, Gärtner J, Lees JA, Colas P.
    Cell Cycle. 2016;15(5):678-88.

    CDK10/cyclin M is a protein kinase that controls  ETS2 degradation and is deficient in STAR syndrome.
    Guen VJ, Gamble C, Flajolet M, Unger S, Thollet A, Ferandin Y, Superti-Furga A, Cohen PA, Meijer L, Colas P.
    Proc Natl Acad Sci U S A. 2013 Nov 26;110(48):19525-30.

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