Gaeatan Pascreau

Study of Aurora protein kinases during Xenopus laevis oocyte maturation.

Abstract:
Aurora proteins belong to a family of kinases involved in the progresion of mitosis. Deregulation of the expression or activity of these kinases causes alterations in the cell cycle leading to the appearance of tumors. During my work I studied Aurora-A and B kinases in Xenopus. We have shown that Aurora-A protein kinase is phosphorylated on threonine 295 necessary for its activity and that the phosphorylation of serine 349 negatively regulates this activity. Aurora-A is involved in oocyte maturation We have characterized a substrate of the Aurora-A kinase, maskin. Our results suggest a role of the Aurora-A protein in the regulation of sequential translation of mRNAs encoding the key proteins of oocyte maturation. In a second step we showed the expression and the biphasic activity of the Aurora-B kinase during oocyte maturation.

Financial support:
Ministère

Committee: December 17th 2004
Thierry Lorca
Robert Bellé
Catherine Jessus
Elisabeth Mandart
Michel Philippe
Yannick Arlot-Bonnemains (Directrice de thèse)

Subscribe to our newsletter