Valérie DUPÉ


Staff scientist

Véronique DAVID Group

+33 (0)2 23 23 38 07

Villejean campus / Building 4 / Room 207

In a few words

After having acquired a strong background in vertebrate development at the IGBMC (Strasbourg, France) and at KCL (London, U.K), I have joined the IGDR (Rennes, France). I have largely contributed to the understanding of the mechanisms implicating retinoic acid during brain development and cranial neural crest cells differentiation. The goal of my research project at the IGDR is now to understand molecular events that are engaged during early forebrain development. 

Major publications

  • Targeted panel sequencing establishes the implication of planar cell polarity pathway and involves new candidate genes in neural tube defect disorders. Beaumont M, Akloul L, Carré W, Quélin C, Journel H, Pasquier L, Fradin M, Odent S, Hamdi-Rozé H, Watrin E, Dupé V, Dubourg C and David V. Human Genetics. 2019 Jan.

    Integrated Clinical and Omics Approach to Rare Diseases : Novel Genes and Oligogenic Inheritance in Holoprosencephaly. Kim A, Savary C, Dubourg C, Carré W, Mouden C, Hamdi-Rozé H, Guyodo H, Le Douce J, Frex Consortium, GoNL Consortium, Pasquier L, Flori E, Gonzales M, Bénéteau C, Boute 0, Attié-Bitach T, Roume J, Goujon L, Akloul L, Odent S, Watrin E, Dupé V, de Tayrac M, David V. Brain. 2019 Jan.

    Recent advances in understanding inheritance of holoprosencephaly. Dubourg C, Kim A, Watrin E, de Tayrac M, Odent S, David V, Dupé V. Am J Med Genet. C. 2018 May.

    [From cyclops to reality: a fresh look at the genetics of holoprosencephaly]. Dupé V, Dubourg C, de Tayrac M, David V. Médecine/Science. 2017 Nov. French

    Regulation of downstream neuronal genes by proneural transcription factors during initial neurogenesis in the vertebrate brain. Ware M, Hamdi-Rozé H, Le Friec J, David V, Dupé V. Neural Development. 2016 Dec.

    Complex mode of inheritance in holoprosencephaly revealed by whole exome sequencing.
    Mouden C, Dubourg C, Carré W, Rose S, Quelin c, Akloul L, Viot G, Salhi H, Darnault P, Odent S, Dupé V, David V.
    Clin. Genet. 2016 Jan.

    Evolutionary conservation of the early axon scaffold in the vertebrate brain. 
    Ware M, Dupé V, Schubert FR.
    Dev. Dyn. 2015 Oct.

    Dynamic expression of Notch-dependent neurogenic markers in the embryonic nervous system of the chick. 
    Ratié L, Ware M, Jagline H, David V, Dupé V.
    Front Neuroanat. 2014 Dec

    Notch signaling and proneural genes work together to control the neural building blocks for the initial scaffold in the hypothalamus. 
    Ware M, Hamdi-Rozé H, Dupé V.
    Front Neuroanat. 2014 Dec.

    NODAL and SHH dose-dependent double inhibition promotes an HPE-like phenotype in chick embryo. 
    Mercier S, David V, Ratié L, Gicquel I, Odent S, Dupé V.
    Dis Model Mech. 2013 Mar.

    Novel genes upregulated when NOTCH signalling is disrupted during hypothalamic development. 
    Ratié L, Ware M, Barloy-Hubler F, Romé H, Gicquel I, Dubourg C, David V, Dupé V.
    Neural Development. 2013 Dec.

    NOTCH, a new signaling pathway implicated in holoprosencephaly. 
    Dupé V, Rochard L, Mercier S, Le Pétillon Y, Gicquel I, Bendavid C, Bourrouillou G, Usha K, Thauvin-Robinet C, Bohan T, Odent S, Dubourg C, David V.
    Hum Mol Genet. 2011 Mar.

    All publications

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