Grégoire MICHAUX Group

Molecular mechanisms of epithelial polarity maintenance

Grégoire MICHAUX

Group Leader

> Email: gmichaux@univ-rennes1.fr

> Phone: + 33 (0)2 23 23 47 75

> Phone: + 33 (0)6 79 53 85 22

Epithelial cells which cover external and internal surfaces of the body and of all organs perform essential function such as barrier, absorption, filtration or respiration. These functions requires the establishment and the maintenance of a cell polarity specific to epithelial cells. Our team seeks to identify and characterise the key factors essential for the maintenance of epithelial polarity in the intestine for food absorption and in the epidermis during morphogenesis.

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Major publications

Selected Publications

  • Simultaneous regulation of cytokinetic furrow and nucleus positions by cortical tension contributes to proper DNA segregation during late mitosis
    Pacquelet A, Jousseaume M, Etienne J, Michaux G.
    2019, in press at Current Biology; 2019, BioRxiv

    Force Transmission between Three Tissues Controls Bipolar Planar Polarity Establishment and Morphogenesis
    Gillard G, Nicolle O, Brugière T, Prigent S, Pinot M, Michaux G.
    2019, Current Biology

    V0-ATPase-dependent apical trafficking maintains the polarity of the intestinal absorptive membrane
    Bidaud-Meynard A, Nicolle O, Heck M, Le Cunff Y, Michaux G.
    2019, Development

    PAR-4 and anillin regulate myosin to coordinate spindle and furrow position during asymmetric division.
    Pacquelet A, Uhart P, Tassan JP, Michaux G.
    2015, Journal of Cell Biology

    Control of E-cadherin apical localisation and morphogenesis by a SOAP-1/AP-1/clathrin pathway in C. elegans epidermal cells.
    Gillard G, Shafaq-Zadah M, Nicolle O, Damaj, R, Pécréaux J, Michaux G.
    2015, Development

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