Olivier DELALANDE

Information

Research professor

Jean-François HUBERT Group

+33 (0)2 23 23 30 07

Villejean Campus / Building 5 / Room 906 (basement)

Responsibilities

President of the Association of the Teacher-Researcher in Pharmacy in Rennes (AECPHAR).

Secretary of the GGMM, Modelling Group of the French Society of Biophysics.

 

In a few words

After a PhD thesis in molecular modelling (LCBPT, Paris Descartes ; Biophysic Institute of Brno, CZ), Olivier Delalande press ahead with the study of biomolecular systems related to human health in the context of large national projects (iBiTecS/CEA-Saclay, IBPC/CNRS Paris and CBM/CNRS Orléans). Associate professor at the Pharmacy Faculty of Rennes since 2010, he does participate for several years to the development of interactive methods for the simulation of biomolecular systems associated with pathologies (myopathies, cancers). His main goals are dealing with the determination of three-dimensional structure of biomolecules, of structure-activity relationships and of molecular interactions in large biological assemblies. He is particularly interested in molecular process induced by genetic mutation and leading to human pathologies. His main biological research topic concentrates on the molecular interactions in muscular dystrophies (myopathies). He is notably studying how sarcolemma molecular organization is modified in the absence or in the truncation of dystrophin, an essential protein of muscular cells.

Major publications

  • Molza, A.-E., Mangat, K., Le Rumeur, E., Hubert, J.-F., Menhart, N. & Delalande, O., Structural basis of neuronal nitric-oxide synthase interaction with dystrophin repeats 16 and 17, J. Biol. Chem., 290(49), 29531-41 (2015)

    Fouqué, A., Delalande, O., Jean, M., Castellano, R., Josselin, E., Malleter, M., Shoji, K. F., Hung, M. D., Rampanarivo, H., Collette, Y., van de Weghe, P. & Legembre, P., A novel covalent mTOR inhibitor, DHM25, shows in vivo antitumor activity against triple-negative breast cancer cells, J. Med. Chem., 58(16), 6559-73 (2015)

    Rau, F., Lainé, J., Ramanoudjame, L., Ferry, A., Arandel, L., Delalande, O., Jollet, A., Dingli, F., Lee, K.-Y., Peccate, C., Lorain, S., Kabashi, E., Athansopoulos, T., Koo, T., Loew, D., Swanson, M., Le Rumeur, E., Dickson, G., Allamand, V., Marie, J. & Furling, D., Abnormal splicing switch of DMD's penultimate exon compromises muscle fiber maintenance in Myotonic Dystrophy, Nat. Commun., 6, 7205 (2015)

    Molza, A.-E., Férey, N., Czjzek, M., Le Rumeur, E., Hubert, J.-F., Tek, A., Laurent, B., Baaden, M. & Delalande, O., Innovative interactive flexible docking method for multi-scale reconstruction elucidates dystrophin molecular assembly, Faraday Discuss., 169, 45-62  (2014)

    Giudice, E., Molza, A.-E., Laurin, Y., Nicolas, A., Le Rumeur, E. & Delalande, O., Molecular clues to the dystrophin-nNOS interaction: a theoretical approach, Biochemistry, 52(44), 7777-84 (2013)

    Delalande, O., Sacquin-Mora, S., & Baaden, M., Conformational substates of Mycobacterium Tuberculosis guanylate kinase reveal structural fluctuations linked to enzymatic function, Biophys. J., 101, 1440-1449 (2011)

    Legrand, B., Giudice, E., Nicolas, A., Delalande, O., & Le Rumeur, E., Computational study of the human dystrophin repeats: interaction properties and molecular dynamics, PloS ONE, 6, e23819 (2011)

    Delalande, O., Desvaux, H., Godat, E., Valleix, A., Junot, C., Labarre, J., & Boulard, Y., Cadmium-glutathione solution structures provide new insights into heavy metal detoxification, FEBS J., 277(24), 5086-96 (2010)

    Saladin, A., Amourda, C., Poulain, P., Férey, N., Baaden, M., Zacharias, M., Delalande, O., & Prévost, C., Modelling the early stage of DNA sequence recognition within RecA nucleoprotein filaments, Nucleic Acids Res., 38, 6313-23 (2010)

    Delalande, O., Férey, N., Grasseau, G. & Baaden, M., Complex molecular assemblies at hand via interactive simulations, J. Comp. Chem., 30, 2375-87 (2009)

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