Marie-Dominique GALIBERT Group

Gene Expression and Oncogenesis (GEO)

Marie-Dominique GALIBERT

Group Leader

> Email: marie-dominique.galibert-anne@univ-rennes1.fr

> Phone: +33 (0)2 23 23 47 05

The GEO team focuses on understanding the genetics mechanisms implicated in the transcriptional regulations that support tumour initiation and development. Two cancer diseases are under study : the UV-dependent skin cancers including melanoma and the ETV6/RUNX1-positive acute lymphoblastic leukemia (ALL).

Major publications

Selected Publications

  • Sustained activation of the Aryl hydrocarbon Receptor transcription factor promotes resistance to BRAF-inhibitors in melanoma. 
    Corre S*, Tardif N*, Mouchet N, Leclair HM, Boussemart L, Gautron A, Bachelot L, Perrot A, Soshilov A, Rogiers A, Rambow F, Dumontet E, Tarte K, Bessede A, Guillemin GJ, Marine JC, Denison MS, Gilot D*, Galibert MD*.
    Nat. Commun. 2018 Nov. - * Equal contribution 

    Interplay between transcription regulators RUNX1 and FUBP1 activates an enhancer of the oncogene c-KIT and amplifies cell proliferation. 
    Debaize L*, Jakobczyk H*, Avner S, Gaudichon J, Rio AG, Sérandour AA, Dorsheimer L, Chalmel F, Carroll JS, Zörnig M, Rieger MA, Delalande O, Salbert G, Galibert MD, Gandemer V, Troadec MB.
    Nucleic Acids Res. 2018 Nov. - * Equal contribution 

    A noncoding function of TYRP1 mRNA promotes melanoma growth. 
    Gilot D*, Migault M*, Bachelot L, Journé F, Rogiers A, Donnou-Fournet E, Mogha A, Mouchet N, Pinel-Marie ML, Mari B, Montier T, Corre S, Gautron A, Rambow F, El Hajj P, Ben Jouira R, Tartare-Deckert S, Marine JC, Felden B, Ghanem G and Galibert MD. 
    Nature Cell Biology. 2017 Nov. * Co-first author

     

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