Group leader

Claude PRIGENT Group

+33 (0)2 23 23 47 31

Villejean Campus / Building 4 / Room 330/2

In a few words

DUT Mesures Physiques - 1980
PhD Biology - 1990
Post-doc Imperial research Fund, Clare Hall Laboratories, South Mimms, UK (1990-1993)
Group leader of the Cell Cycle team since 1996
Scientific Director MRic (Microscopy Rennes Imaging Center, IBiSA)  (2000-2016) then Scientific Advisor for MRic
Director Institute of Genetics and Development of Rennes IGDR UMR 6290 CNRS UR1 (2004-2016)
Research Director CNRS since 2002
Associate Professor University Laval, Quebec, Canada (April 2014 – April 2017)

Major publications

  • Aurora kinase A localises to mitochondria to control organelle dynamics and energy production
    Bertolin G*, Bulteau AL, Alves-Guerra MC, Burel A, Lavault MT, Gavard O, Le Bras S, Gagné JP, Poirier GG, Le Borgne R, Prigent C*, Tramier M*
    Elife. 2018 [Epub ahead of print]

    Aurora A activation in mitosis promoted by BuGZ.
    Huang Y, Li T, Ems-McClung SC, Walczak CE, Prigent C, Zhu X, Zhang X, Zheng Y.
    J Cell Biol. 2018 Jan 2

    Aurora A Kinase Is a Priority Pharmaceutical Target for the Treatment of Cancers.
    Damodaran AP, Vaufrey L, Gavard O, Prigent C.
    Trends Pharmacol Sci. 2017 Aug

    A FRET biosensor reveals spatiotemporal activation and functions of aurora kinase A in living cells.
    Bertolin G, Sizaire F, Herbomel G, Reboutier D, Prigent C, Tramier M.
    Nat Commun. 2016 Sep 14;7:12674.

    Annexin A2 is required for the early steps of cytokinesis.
    Benaud C, Le Dez G, Mironov S, Galli F, Reboutier D, Prigent C.
    EMBO Rep. 2015 Apr;16(4):481-9.

    Sororin pre-mRNA splicing is required for proper sister chromatid cohesion in human cells.
    Watrin E, Demidova M, Watrin T, Hu Z, Prigent C.
    EMBO Rep. 2014 Sep;15(9):948-55.

    Aurora A is involved in central spindle assembly through phosphorylation of Ser19 in P150Glued.
    Reboutier D, Troadec MB, Cremet JY, Chauvin L, Guen V, Salaun P, Prigent C
    J Cell Biol. 2013 Apr 1;201(1):65-79.

    Nucleophosmin/B23 activates Aurora A at the centrosome through phosphorylation of serine 89.
    Reboutier D, Troadec MB, Cremet JY, Fukasawa K, Prigent C.
    J Cell Biol. 2012 Apr 2;197(1):19-26.

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