Régis GIET Group

Cytoskeleton and Cell proliferation (CCP)

Régis GIET

Group leader

> Email: Regis.Giet@univ-rennes1.fr

> Phone: +33 2 23 23 49 98

> Biography


Assembly of the mitotic spindle during cell division, a microtubule-based structure, is crucial for equal chromosome distribution in the daughter cells. Furthermore, the correct positioning of the spindle along the cell polarity axis is required for asymmetric delivery of cell fate, proteins a process that maintains tissue homeostasis. Our research goal is to understand how spindle assembly and positioning is regulated during cell division in developing tissues.

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Major publications

Selected Publications

  • Dual control of Kinesin-1 recruitment to microtubules by Ensconsin in Drosophila neuroblasts and oocytes.
    Métivier M, Monroy BY, Gallaud E, Caous R, Pascal A, Richard-Parpaillon L, Guichet A, Ori-McKenney KM, Giet R.
    Development. 2019 Apr 17;146(8). pii: dev171579. doi: 10.1242/dev.171579.

    14-3-3 regulation of Ncd reveals a new mechanism for targeting proteins to the spindles in oocytes.
    Beaven R, Bastos RN, Spanos C, Romé P, Cullen CF, Rappsilber J, Giet R, Goshima G, Ohkura H.
    J Cell Biol. 2017 Oct 2;216(10):3029-3039 

    Spindle assembly checkpoint inactivation fails to suppress neuroblast tumour formation in aurA mutant Drosophila.
    Caous R, Pascal A, Romé P, Richard-Parpaillon L, Karess R, Giet R.
    Nat Commun. 2015 Nov

    Ensconsin/Map7 promotes microtubule growth and centrosome separation in Drosophila neural stem cells.
    Gallaud E, Caous R, Pascal A, Bazile F, Gagné JP, Huet S, Poirier GG, Chrétien D, Richard-Parpaillon L, Giet R.
    J Cell Biol. 2014 Mar.

    CDK11(p58) is required for centriole duplication and Plk4 recruitment to mitotic centrosomes.
    Franck N, Montembault E, Romé P, Pascal A, Cremet JY, Giet R.
    PLoS One. 2012 Jan.

    Aurora A contributes to p150(glued) phosphorylation and function during mitosis.
    Romé P, Montembault E, Franck N, Pascal A, Glover DM, Giet R.
    J Cell Biol. 2010 May.

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