Roland LE BORGNE Group

Epithelia Dynamics and Mechanics

Roland LE BORGNE

Group leader

> Email: roland.leborgne@univ-rennes1.fr

> Phone: +33 2 23 23 48 94

> Phone: +33 6 86 05 89 23

During development and throughout adult life, cell-fate diversity is in part generated via asymmetric cell divisions. Our team is studying how a cell divides to produce two daughter cells with different identities and how deregulation of asymmetric division is responsible for various types of pathologies, including cancers.

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Major publications

Selected Publications

  • Mss4/Stratum activates Rab8 to regulate Golgi exit and basolateral sorting of Notch and Sanpodo

    Bellec, K., Gicquel, I; and Le Borgne R.

    2018, July2; 145 (13) pii: dev163469. doi: 10.1242/dev.163469.

     

    Coordination of Septate Junctions Assembly and Compeltion of Cytokinesis in Proliferative Epithelial Tissues

    Daniel, E., Daudé, M., Kolotuev, I., Charish, K., Auld, V., Le Borgne R.

    2018 May 7;28(9):1380-1391.e4. doi: 10.1016/j.cub.2018.03.034.

     

    Drosophila E-cadherin is required for the maintenance of ring canals anchoring to mechanically withstand tissue growth
    Loyer N., Kolotuev I., Pinot M., Le Borgne R.
    2015 Oct 13;112(41):12717-22.

    Numb inhibits the recycling of Sanpodo in Drosophila sensory organ precursor
    Cotton M, Benhra N, Le Borgne R.
    Curr Biology. 2013 Apr.
    Comment in Current Biology 23 (7) R270-2

    Septins regulate the contractility of the actomyosin ring to enable adherens junction remodeling during cytokinesis of epithelial cells
    Founounou N, Loyer N, Le Borgne R.
    Dev Cell. 2013 Feb.
    Cited in Faculty of 1000 Biology & comment in Developmental Cell 24(4) 336-8

    AP-1 controls the trafficking of Notch and Sanpodo toward E-Cadherin junctions in sensory organ precursors
    Benhra N, Lallet L, Cotton M, Le Bras S, Dussert A, Le Borgne R.
    Curr Biology. 2011 Jan

     

    In Collaboration 

    Aurora A kinase localizes to mitochondria to control organelle dynamics and energy production. Bertolin, G., Bulteau, A-L., Alves-Guerra, M-C, Burel, A., Lavault, M-T, Gavard, O., Le Bras, S., Gagné, J-P, Poirier, G., Le Borgne  R., Prigent, C., Tramier, M. eLife 2018, accepted for publication August 2

    Centrosomal ALIX Regulates Mitotic Spindle Orientation by Modulating Astral Microtubule Dynamics. Malerød, L., Le Borgne, R., Lie-Jensen, A. , Eikenes Å.-H., Brech, A., Liestøl, K., Stenmark, H. and Haglund, K. EMBO J. 2018 Jul 2;37(13). pii: e97741. doi: 10.15252/embj.201797741. Epub 2018 Jun 1.

    Remodeling of adhesion and modulation of mechanical tensile forces during apoptosis in Drosophila epithelium Teng X, Qin L, Le Borgne R, Toyama Y Development. 2017 Jan 1;144(1):95-105.

    Spatiotemporal control of microtubule nucleation and assembly using magnetic nanoparticle Hoffmann,C.,  Mazari, E., Lallet, S., Le Borgne, R., Marchi-Artzner, V., Gosse, C. and Gueroui, Z. Nat Nanotechnol. 2013 Mar;8(3):199-205.

    Drosophila S2 cells secrete wingless on exosome-like vesicles but the wingless gradient forms independently of exosomes Beckett K, Monier S, Palmer L, Alexandre C, Green H, Bonneil E, Raposo G, Thibault P, Le Borgne R, Vincent JP.Traffic. 2013 Jan;14(1):82-96.

     

    Review

    Epithelial cell division-multiplying without losing touch Le Bras S., Le Borgne R. J Cell Sci. 2014 Dec 15;127(Pt 24):5127-37.

    The roles of receptor and ligand endocytosis in regulating Notch signaling. Le Borgne R, Bardin A, Schweisguth F. Development. 2005 Apr;132(8):1751-62

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