Yannick ARLOT Group

Molecular Bases of Tumorigenesis : VHL disease

Yannick ARLOT

Group leader

> Email : yannick.arlot@univ-rennes1.fr

> Phone : + 33 (0)2 23 23 46 96

Functions of VHL isoforms in tumorigenesis progression

The Von Hippel Lindau (VHL) disease is a rare autosomal-dominant hereditary neoplastic disease associated with germline loss-of-function mutations of the VHL gene. Patients affected by the VHL disease may develop both benign and malignant tumors including clear-cell renal cell carcinoma (ccRCC), retinal angioma, cerebellar and spinal hemangioblastoma, pheochromocytoma and pancreatic cancers. We investigate the functions of VHL in the process of tumorigenesis

Major publications

Selected Publications

  • The pVHL172 isoform is not a tumor suppressor and up-regulates a subset of pro-tumorigenic genes including TGFB1 and MMP13
    P Hascoet ,  F Chesnel, F Jouan , C Le Goff , A Couturier, E Darrigrand , F Mahé , N Rioux-Leclercq ,  X Le Goff , Y Arlot-Bonnemains  
    Oncotarget - April 2017- accepted 

    Deregulated expression of VHL mRNA variants in papillary thyroid cancer
    Baldini E, ,Tucilli C Arlot-Bonnemains  Y Chesnel, F, Sorrenti S, De Vito C, Catania A, D’Arminento e, Entonelli A, Fallahi P, Watutantrige S, Tartaglia F, Barollo S Mian C, Bononi M, Arceri,S, Mascagni D, Vergine M, Pironi D, Monti M, Fillipini A, Ulisse SW
    Mol. Cell. Endocrinol.  2017

    Expression and prognostic value of the cell polarity PAR complex members in thyroid cancer.
    Tuccilli C, Baldini E, Arlot-Bonnemains Y, Chesnel F, Sorrenti S, De Vito C, D'Armiento E, Antonelli A, Fallahi P, Watutantrige S, Tartaglia F, Barollo S, Mian C, Arcieri S, Mascagni D, Pironi D, Bononi M, Vergine M, Monti M, Filippini A, Ulisse S.
    ​Int J Oncol. 2017 Mar 

    SHIP2 regulates lumen generation, cell division and ciliogenesis through the control of basolateral to apical lumen localization of Aurora A and HEF 1
    O Hamze Komaiha, S Sarr Y Arlot-Bonnemains , DSamuel, and A Gassama-Diagne 1
    Cell Reports  Dec  2016

    Aggregation dynamics and identification of aggregation-prone mutants of the von Hippel Lindau tumor suppressor protein
    Le Goff X, Chesnel, F, Delalande O, Couturier A, Dreano S, Le Goff C, Vigneau C, Arlot-Bonnemains Y
    J Cell Science Mai 2016 

    The Von Hippel Lindau tumor suppressor gene: Uncovering the expression of the pVHL172
    Chesnel F, Hascoet P, GagneJP, Couturier A,  Jouan F, Poirier G, Le Goff C, Vigneau C, Danger Y, Verite F , Le Goff X, & Arlot-Bonnemains
    Br J Cancer. 2015 Jun.

    Unconventional Functions of Mitotic Kinases in Kidney Tumorigenesis 
    Hascoet P, Chesnel F, Le Goff C, Le Goff X, Arlot-Bonnemains Y.
    Front Oncol. 2015 Oct

    Overexpression of the polarity protein PAR-3 in clear cell renal cell carcinoma is associated with poor prognosis
    Dugay F, Le Goff X, Rioux-Leclerq N, Chesnel F, Jouan F, Henry C, Cabillic F, Verhoest G, Vigneau C, Belaud-Rotureau MA and Arlot-Bonnemains Y. (YAB And MABR are co-last authors YAB is the correpsonding  author).
    Int J Cancer. 2014 May 

    Identification of pVHL as a novel substrate for Aurora-A in clear cell renal cell carcinoma  (ccRCC)
    Martin B, Chesnel F, Delcros JG, Jouan F, Couturier A, Dugay F, Le Goff X, Patard JJ, Fergelot P, Vigneau C, Rioux-Leclerq N, Arlot-Bonnemains Y
    PLoS One. 2013 Jun 13

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