Reynald Gillet group - Ribosome, bacteria and stress

Most of the functions within living organisms are performed by biomolecules named proteins. Protein synthesis is accomplished through a process known as translation and is carried out by the ribosome, a molecular machine found in every living cell. Our team is dedicated to the study of the way cells generate proteins, by electron microscopy, biochemistry, molecular biology and bioinformatics.

Major publications

The structure of an elongation factor G-ribosome complex captured in the absence of inhibitors.
Macé K, Giudice E, Chat S, Gillet R.
Nucleic Acid Res. 2018 Apr.

A Genetic Tool to Quantify trans-Translation Activity in Vivo.
Macé K, Demay F, Guyomar C, Georgeault S, Giudice E, Goude R, Trautwetter A, Ermel G, Blanco C, Gillet R.
J. Mol. Biol. 2017 Nov.

Mechanism of eIF6 release from the nascent 60S ribosomal subunit.
Weis F, Giudice E, Churcher M, Jin L, Hilcenko C, Wong CC, Traynor D, Kay RR, Warren AJ.
Nat. Struct. Mol. Biol. 2015 Nov.

The task force that rescues stalled ribosomes in bacteria.
Giudice E, Gillet R.
Trends Biochem Sci. 2013 Aug.

Decoding in the absence of a codon by tmRNA and SmpB in the ribosome.
Neubauer C, Gillet R, Kelley AC, Ramakrishnan V.
Science. 2012 Mar.