Stéphanie MOTTIER

Email : stephanie [dot] mottier [at] univ-rennes1 [dot] fr

Phone : +33 (0)2 23 23 45 46

Office number : Villejean / Bât 4 / 210-1

En quelques mots

Je suis ingénieure d'études au CNRS.

Je suis bio-informaticienne et bio-analyste. Je développe et met en oeuvre des outils informatiques pour le traitement, l'analyse et la visualisation de données de génomique, issues de séquençage à très haut débit (WGS, RNA-seq, WES). L'analyse de ces données NGS visant à l'identification d'ARN ou la caractérisation de mutations liées à des maladies génétiques.

Responsabilités

  • Encadrement d'étudiants (Licence à Maîtrise).
  • Web manager des sites WEB de l'équipe

Responsabilités partagées

  • Gestion d'un appareil de révélation de Wertern Blot en fluorescence ( LI-COR Odyssey® imaging systems).

Publications majeures

  • Broeckx BJG, Derrien T, Mottier S, Wucher V, Cadieu E, Hédan B, Le Béguec C, Botherel N, Lindblad-Toh K, Saunders JH, Deforce D, André C, Peelman L, Hitte C. An exome sequencing based approach for genome-wide association studies in the dog. Sci Rep. 2017 Nov 15;7(1):15680. doi: 10.1038/s41598-017-15947-9. PubMed PMID: 29142306; PubMed Central PMCID: PMC5688105.
  • Noiret M, Mottier S, Angrand G, Gautier-Courteille C, Lerivray H, Viet J, Paillard L, Mereau A, Hardy S, Audic Y. Ptbp1 and Exosc9 knockdowns trigger skin stability defects through different pathways. Dev Biol. 2016 Jan 15;409(2):489-501. doi: 10.1016/j.ydbio.2015.11. 002. Epub 2015 Nov 4. PubMed PMID: 26546114.
  • Edeline J, Mottier S, Vigneau C, Jouan F, Perrin C, Zerrouki S, Fergelot P, Patard JJ, Rioux-Leclercq N. Description of 2 angiogenic phenotypes in clear cell renal cell carcinoma. Hum Pathol. 2012 Nov;43(11):1982-90. doi:10.1016/j.humpath.2012.01.023. Epub 2012 May 22. PubMed PMID: 22626276.
  • Collet N, Théoleyre S, Rageul J, Mottier S, Jouan F, Rioux-Leclercq N, Fergelot P, Patard JJ, Masson D, Denis MG. PPARγ is functionally expressed in clear cell renal cell carcinoma. Int J Oncol. 2011 Mar;38(3):851-7. doi: 10.3892/ijo.2010.891. Epub 2010 Dec 28. PubMed PMID: 21206970.
  • Dolley-Hitze T, Jouan F, Martin B, Mottier S, Edeline J, Moranne O, Le Pogamp P, Belaud-Rotureau MA, Patard JJ, Rioux-Leclercq N, Vigneau C. Angiotensin-2 receptors (AT1-R and AT2-R), new prognostic factors for renal clear-cell carcinoma? Br J Cancer. 2010 Nov 23;103(11):1698-705. doi: 10.1038/sj.bjc.6605866. PubMed PMID: 21102591; PubMed Central PMCID: PMC2994218.
  • Verhoest G, Patard JJ, Fergelot P, Jouan F, Zerrouki S, Dreano S, Mottier S, Rioux-Leclercq N, Denis MG. Paraffin-embedded tissue is less accurate than frozen section analysis for determining VHL mutational status in sporadic renal cell carcinoma. Urol Oncol. 2012 Jul-Aug;30(4):469-75. doi: 10.1016/j.urolonc.2010.07.005. Epub 2010 Sep 21. PubMed PMID: 20863722.
  • Masson D, Rioux-Leclercq N, Fergelot P, Jouan F, Mottier S, Théoleyre S, Bach-Ngohou K, Patard JJ, Denis MG. Loss of expression of TIMP3 in clear cell renal cell carcinoma. Eur J Cancer. 2010 May;46(8):1430-7. doi: 10.1016/j.ejca.2010.01.009. Epub 2010 Mar 1. PubMed PMID: 20194016.
  • Théoleyre S, Mottier S, Masson D, Denis MG. HtrA3 is regulated by 15-deoxy-Delta12,14-prostaglandin J2 independently of PPARgamma in clear cell renal cell carcinomas. Biochem Biophys Res Commun. 2010 Apr 9;394(3):453-8. doi: 10.1016/j.bbrc.2009.11.163. Epub 2009 Nov 29. PubMed PMID: 19951697.
  • Rageul J, Mottier S, Jarry A, Shah Y, Théoleyre S, Masson D, Gonzalez FJ, Laboisse CL, Denis MG. KLF4-dependent, PPARgamma-induced expression of GPA33 in colon cancer cell lines. Int J Cancer. 2009 Dec 15;125(12):2802-9. doi: 10.1002/ijc.24683. PubMed PMID: 19551868; PubMed Central PMCID: PMC2791338.
  • Gandemer V, Rio AG, de Tayrac M, Sibut V, Mottier S, Ly Sunnaram B, Henry C, Monnier A, Berthou C, Le Gall E, Le Treut A, Schmitt C, Le Gall JY, Mosser J, Galibert MD. Five distinct biological processes and 14 differentially expressed genes characterize TEL/AML1-positive leukemia. BMC Genomics. 2007 Oct 23;8:385. PubMed PMID: 17956600; PubMed Central PMCID: PMC2211320.
  • Bendavid C, Dubourg C, Pasquier L, Gicquel I, Le Gallou S, Mottier S, Durou MR, Henry C, Odent S, David V. MLPA screening reveals novel subtelomeric rearrangements in holoprosencephaly. Hum Mutat. 2007 Dec;28(12):1189-97. PubMed PMID: 17683084.
  • Bouancheau D, Jarry A, Mottier S, Toquet C, Masson D, Mosnier JF, Laboisse CL, Denis MG. Low expression of ORF4, a dominant negative variant of peroxisome proliferator-activated receptor gamma, in colorectal adenocarcinoma. Oncol Rep. 2007 Aug;18(2):489-95. PubMed PMID: 17611675.
  • Abgueguen E, Toutain B, Bédrine H, Chicault C, Orhant M, Aubry M, Monnier A, Mottier S, Jouan H, Bahram S, Mosser J, Fergelot P. Differential expression of genes related to HFE and iron status in mouse duodenal epithelium. Mamm Genome.2006 May;17(5):430-50. PubMed PMID: 16688533.
  • Bourneuf E, Hérault F, Chicault C, Carré W, Assaf S, Monnier A, Mottier S, Lagarrigue S, Douaire M, Mosser J, Diot C. Microarray analysis of differential gene expression in the liver of lean and fat chickens. Gene. 2006 May 10;372:162-70. Epub 2006 Mar 2. PubMed PMID: 16513294.
  • Bédrine-Ferran H, Le Meur N, Gicquel I, Le Cunff M, Soriano N, Guisle I, Mottier S, Monnier A, Teusan R, Fergelot P, Le Gall JY, Léger J, Mosser J. Transcriptome variations in human CaCo-2 cells: a model for enterocyte differentiation and its link to iron absorption. Genomics. 2004 May;83(5):772-89. PubMed PMID: 15081108.
  • Wood V, Gwilliam R, Rajandream MA, Lyne M, Lyne R, Stewart A, Sgouros J, Peat N, Hayles J, Baker S, Basham D, Bowman S, Brooks K, Brown D, Brown S, Chillingworth T, Churcher C, Collins M, Connor R, Cronin A, Davis P, Feltwell T,  Fraser A, Gentles S, Goble A, Hamlin N, Harris D, Hidalgo J, Hodgson G, Holroyd S, Hornsby T, Howarth S, Huckle EJ, Hunt S, Jagels K, James K, Jones L, Jones M, Leather S, McDonald S, McLean J, Mooney P, Moule S, Mungall K, Murphy L, Niblett D, Odell C, Oliver K, O'Neil S, Pearson D, Quail MA, Rabbinowitsch E, Rutherford K, Rutter S, Saunders D, Seeger K, Sharp S, Skelton J, Simmonds M, Squares R,Squares S, Stevens K, Taylor K, Taylor RG, Tivey A, Walsh S, Warren T, Whitehead S, Woodward J, Volckaert G, Aert R, Robben J, Grymonprez B, Weltjens I, Vanstreels E, Rieger M, Schäfer M, Müller-Auer S, Gabel C, Fuchs M, Düsterhöft A, Fritzc C, Holzer E, Moestl D, Hilbert H, Borzym K, Langer I, Beck A, Lehrach H, Reinhardt R, Pohl TM, Eger P, Zimmermann W, Wedler H, Wambutt R, Purnelle B, Goffeau A, Cadieu E, Dréano S, Gloux S, Lelaure V, Mottier S, Galibert F, Aves SJ, Xiang Z, Hunt C, Moore K, Hurst SM, Lucas M, Rochet M, Gaillardin C, Tallada VA, Garzon A, Thode G, Daga RR, Cruzado L, Jimenez J, Sánchez M, del Rey F, Benito J, Domínguez A, Revuelta JL, Moreno S, Armstrong J, Forsburg SL, Cerutti L, Lowe T, McCombie WR, Paulsen I, Potashkin J, Shpakovski GV, Ussery D, Barrell BG, Nurse P. The genome sequence of Schizosaccharomyces pombe. Nature. 2002 Feb 21;415(6874):871-80. Erratum in: Nature 2003 Jan 2;421(6918):94. Cerrutti L [corrected to Cerutti L]. PubMed PMID: 11859360.
  • Peter A, Schöttler P, Werner M, Beinert N, Dowe G, Burkert P, Mourkioti F, Dentzer L, He Y, Deak P, Benos PV, Gatt MK, Murphy L, Harris D, Barrell B, Ferraz C, Vidal S, Brun C, Demaille J, Cadieu E, Dreano S, Gloux S, Lelaure V, Mottier S, Galibert F, Borkova D, Miñana B, Kafatos FC, Bolshakov S, Sidén-Kiamos I, Papagiannakis G, Spanos L, Louis C, Madueño E, de Pablos B, Modolell J, Bucheton A, Callister D, Campbell L, Henderson NS, McMillan PJ, Salles C, Tait E, Valenti P, Saunders RD, Billaud A, Pachter L, Klapper R, Janning W, Glover DM, Ashburner M, Bellen HJ, Jäckle H, Schäfer U. Mapping and identification of essential gene functions on the X chromosome of Drosophila. EMBO Rep. 2002 Jan;3(1):34-8. Epub 2001 Dec 19. PubMed PMID: 11751581; PubMed Central PMCID: PMC1083931.
  • Benos PV, Gatt MK, Murphy L, Harris D, Barrell B, Ferraz C, Vidal S, Brun C, Demaille J, Cadieu E, Dreano S, Gloux S, Lelaure V, Mottier S, Galibert F, Borkova D, Miñana B, Kafatos FC, Bolshakov S, Sidén-Kiamos I, Papagiannakis G, Spanos L, Louis C, Madueño E, de Pablos B, Modolell J, Peter A, Schöttler P, Werner M, Mourkioti F, Beinert N, Dowe G, Schäfer U, Jäckle H, Bucheton A, Callister D, Campbell L, Henderson NS, McMillan PJ, Salles C, Tait E, Valenti P, Saunders RD, Billaud A, Pachter L, Glover DM, Ashburner M. From first base: the sequence of the tip of the X chromosome of Drosophila melanogaster, a comparison of two sequencing strategies. Genome Res. 2001 May;11(5):710-30. PubMed PMID: 11337470; PubMed Central PMCID: PMC311117.
  • Benos PV, Gatt MK, Ashburner M, Murphy L, Harris D, Barrell B, Ferraz C, Vidal S, Brun C, Demailles J, Cadieu E, Dreano S, Gloux S, Lelaure V, Mottier S, Galibert F, Borkova D, Minana B, Kafatos FC, Louis C, Sidén-Kiamos I, Bolshakov S, Papagiannakis G, Spanos L, Cox S, Madueño E, de Pablos B, Modolell J, Peter A, Schöttler P, Werner M, Mourkioti F, Beinert N, Dowe G, Schäfer U, Jäckle H, Bucheton A, Callister DM, Campbell LA, Darlamitsou A, Henderson NS, McMillan PJ, Salles C, Tait EA, Valenti P, Saunder RD, Glover DM. From sequence to chromosome: the tip of the X chromosome of D. melanogaster. Science. 2000 Mar 24;287(5461):2220-2. PubMed PMID: 10731137.