Adresse courriel : jacek [dot] kubiak [at] univ-rennes1 [dot] fr
Téléphone : 02 23 23 46 98
Basic molecular mechanisms of the cell cycle control are common for all eukaryotic cells. However, during developmental processes numerous cell cycle and cell division events are modified to support gametogenesis, fertilization and embryo development. We investigate these processes to identify their molecular mechanisms. We discovered a CDC6-dependent mechanism inhibiting the activity of the main M-phase kinase CDK1 in oocytes and early embryos. This mechanism regulates the dynamics of CDK1 activation upon M-phase entry and therefore tunes the timing of the M-phase entry and progression in embryos. Using the advantage of Drosophila melanogastre model system we will analyse details of the CDC6-dependent inhibitory mechanism acting on CDK1 and potentially regulting the mitotic events also during later stages of development.
Key recent publications
El Dika M, Laskowska-Kaszub K, Koryto M, Dudka D, Prigent C, Tassan JP, Kloc M, Polanski Z, Borsuk E, Kubiak JZ. (2014). CDC6 controls dynamics of the first embryonic M-phase entry and progression via CDK1 inhibition. Dev Biol. 396 (1):67-80.
Debowski M., El Dika M., Malejczyk J., Zdanowski R., Prigent C., Tassan J.-P., Kloc M., Lachowicz M., Kubiak J.Z. (2016). Flexibility vs. robustness in cell cycle control: mathematical model of interplay between CDK1, PP2A and CDC25 in regulation of timing of M-phase entry in Xenopus laevis embryo cell-free extract. Intl. J. Dev. Biol. 60(7-8-9):305-314.
Borsuk E., Jachowicz J., Kloc M., Tassan J.-P., Kubiak J.Z. (2017). Role of Cdc6 during oogenesis and early embryo development in mouse and Xenopus laevis. Results Probl Cell Differ. 59:201-211.
Debowski M, Szymanska Z, Kubiak JZ, Lachowicz. (2019). Mathematical Model Explaining the Role of CDC6 in the Diauxic Growth of CDK1 Activity during the M-Phase of the Cell Cycle. Cells 8(12):1537.